Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy

In the initial stage of retinopathy of prematurity (ROP), hyperoxia causes retinal blood vessel obliteration. This is thought to occur in part through oxidative stress-induced apoptosis of endothelial cells. This study was designed to determine what role NF-E2-related factor 2 (Nrf2) plays in this p...

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Veröffentlicht in:	Experimental eye research 2010-04, Vol.90 (4), p.493-500
Hauptverfasser:	Uno, Koichi, Prow, Tarl W., Bhutto, Imran A., Yerrapureddy, Adi, McLeod, D. Scott, Yamamoto, Masayuki, Reddy, Sekhar P., Lutty, Gerard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Animals Animals, Newborn Apoptosis Blood vessels Capillaries Cryopreservation development Disease Models, Animal Endothelial cells Eye Female Fluorescent Antibody Technique, Indirect Humans Hyperoxia Hyperoxia - metabolism Infant, Newborn Lectins Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal NF-E2-Related Factor 2 - physiology Nrf2 Oxidative stress Oxygen - toxicity Reactive Oxygen Species Regulatory sequences Retina Retinal Artery Occlusion - metabolism Retinal Vein Occlusion - metabolism Retinal Vessels - growth & development Retinopathy retinopathy of prematurity Retinopathy of Prematurity - etiology Retinopathy of Prematurity - metabolism Reverse Transcriptase Polymerase Chain Reaction Survival Transcription factors
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