Wnt inhibition enhances browning of mouse primary white adipocytes

Wnt inhibition enhances browning of mouse primary white adipocytes

The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose ti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Adipocyte 2016-04, Vol.5 (2), p.224-231
Hauptverfasser: Lo, Kinyui Alice, Ng, Pei Yi, Kabiri, Zahra, Virshup, David, Sun, Lei
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 231
container_issue 2
container_start_page 224
container_title Adipocyte
container_volume 5
creator Lo, Kinyui Alice
Ng, Pei Yi
Kabiri, Zahra
Virshup, David
Sun, Lei
description The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a potential anti-obesity target. Various signaling pathways can enhance browning. Wnt is a key regulator of adipocyte biology, but its role in browning has not been explored. In this study, we found that in primary mouse adipocytes derived from the inguinal depot, Wnt inhibition by both chemical and genetic methods significantly enhanced browning. The effect of Wnt inhibition on browning most likely targets the beige precursor cells in selected adipose depots.
doi_str_mv 10.1080/21623945.2016.1148834
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4916886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1802738021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-fc4042441dd8017da2d15b6bb910012d6661dc335659f829c951747343a424dd3</originalsourceid><addsrcrecordid>eNpVUU1PwzAMjRCITWM_AdQjl404SdP0ggQTX9IkLiC4RWmSrkFbMpqOaf-eVusm8MWW7ff88RC6BDwFLPANAU5oztIpwcCnAEwIyk7QsMtPaJ59nh5jlg7QOMYv3BrHKWdwjgYko4K39SG6__BN4nzlCte44BPrK-W1jUlRh613fpGEMlmFTbTJunYrVe-SbeUamyjj1kHvGhsv0FmpltGOez9C748Pb7Pnyfz16WV2N59oBtBMSs0wI4yBMQJDZhQxkBa8KHLAGIjhnIPRlKY8zUtBcp2nkLGMMqpamDF0hG73vOtNsbJGW9_Uain7tWRQTv6veFfJRfiRLAcuBG8JrnuCOnxvbGzkykVtl0vlbXuhBIG7x2ACbWu6b9V1iLG25XEMYNlJIA8SyE4C2UvQ4q7-7nhEHR5OfwGeQ4F7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1802738021</pqid></control><display><type>article</type><title>Wnt inhibition enhances browning of mouse primary white adipocytes</title><source>Taylor &amp; Francis Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Lo, Kinyui Alice ; Ng, Pei Yi ; Kabiri, Zahra ; Virshup, David ; Sun, Lei</creator><creatorcontrib>Lo, Kinyui Alice ; Ng, Pei Yi ; Kabiri, Zahra ; Virshup, David ; Sun, Lei</creatorcontrib><description>The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a potential anti-obesity target. Various signaling pathways can enhance browning. Wnt is a key regulator of adipocyte biology, but its role in browning has not been explored. In this study, we found that in primary mouse adipocytes derived from the inguinal depot, Wnt inhibition by both chemical and genetic methods significantly enhanced browning. The effect of Wnt inhibition on browning most likely targets the beige precursor cells in selected adipose depots.</description><identifier>ISSN: 2162-3945</identifier><identifier>EISSN: 2162-397X</identifier><identifier>DOI: 10.1080/21623945.2016.1148834</identifier><identifier>PMID: 27386162</identifier><language>eng</language><publisher>United States: Taylor &amp; Francis</publisher><subject>Brief Report</subject><ispartof>Adipocyte, 2016-04, Vol.5 (2), p.224-231</ispartof><rights>2016 The Author(s). Published with license by Taylor &amp; Francis Group, LLC 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-fc4042441dd8017da2d15b6bb910012d6661dc335659f829c951747343a424dd3</citedby><cites>FETCH-LOGICAL-c411t-fc4042441dd8017da2d15b6bb910012d6661dc335659f829c951747343a424dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916886/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916886/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27386162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lo, Kinyui Alice</creatorcontrib><creatorcontrib>Ng, Pei Yi</creatorcontrib><creatorcontrib>Kabiri, Zahra</creatorcontrib><creatorcontrib>Virshup, David</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><title>Wnt inhibition enhances browning of mouse primary white adipocytes</title><title>Adipocyte</title><addtitle>Adipocyte</addtitle><description>The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a potential anti-obesity target. Various signaling pathways can enhance browning. Wnt is a key regulator of adipocyte biology, but its role in browning has not been explored. In this study, we found that in primary mouse adipocytes derived from the inguinal depot, Wnt inhibition by both chemical and genetic methods significantly enhanced browning. The effect of Wnt inhibition on browning most likely targets the beige precursor cells in selected adipose depots.</description><subject>Brief Report</subject><issn>2162-3945</issn><issn>2162-397X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVUU1PwzAMjRCITWM_AdQjl404SdP0ggQTX9IkLiC4RWmSrkFbMpqOaf-eVusm8MWW7ff88RC6BDwFLPANAU5oztIpwcCnAEwIyk7QsMtPaJ59nh5jlg7QOMYv3BrHKWdwjgYko4K39SG6__BN4nzlCte44BPrK-W1jUlRh613fpGEMlmFTbTJunYrVe-SbeUamyjj1kHvGhsv0FmpltGOez9C748Pb7Pnyfz16WV2N59oBtBMSs0wI4yBMQJDZhQxkBa8KHLAGIjhnIPRlKY8zUtBcp2nkLGMMqpamDF0hG73vOtNsbJGW9_Uain7tWRQTv6veFfJRfiRLAcuBG8JrnuCOnxvbGzkykVtl0vlbXuhBIG7x2ACbWu6b9V1iLG25XEMYNlJIA8SyE4C2UvQ4q7-7nhEHR5OfwGeQ4F7</recordid><startdate>20160402</startdate><enddate>20160402</enddate><creator>Lo, Kinyui Alice</creator><creator>Ng, Pei Yi</creator><creator>Kabiri, Zahra</creator><creator>Virshup, David</creator><creator>Sun, Lei</creator><general>Taylor &amp; Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160402</creationdate><title>Wnt inhibition enhances browning of mouse primary white adipocytes</title><author>Lo, Kinyui Alice ; Ng, Pei Yi ; Kabiri, Zahra ; Virshup, David ; Sun, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-fc4042441dd8017da2d15b6bb910012d6661dc335659f829c951747343a424dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Brief Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Kinyui Alice</creatorcontrib><creatorcontrib>Ng, Pei Yi</creatorcontrib><creatorcontrib>Kabiri, Zahra</creatorcontrib><creatorcontrib>Virshup, David</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Adipocyte</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Kinyui Alice</au><au>Ng, Pei Yi</au><au>Kabiri, Zahra</au><au>Virshup, David</au><au>Sun, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt inhibition enhances browning of mouse primary white adipocytes</atitle><jtitle>Adipocyte</jtitle><addtitle>Adipocyte</addtitle><date>2016-04-02</date><risdate>2016</risdate><volume>5</volume><issue>2</issue><spage>224</spage><epage>231</epage><pages>224-231</pages><issn>2162-3945</issn><eissn>2162-397X</eissn><abstract>The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a potential anti-obesity target. Various signaling pathways can enhance browning. Wnt is a key regulator of adipocyte biology, but its role in browning has not been explored. In this study, we found that in primary mouse adipocytes derived from the inguinal depot, Wnt inhibition by both chemical and genetic methods significantly enhanced browning. The effect of Wnt inhibition on browning most likely targets the beige precursor cells in selected adipose depots.</abstract><cop>United States</cop><pub>Taylor &amp; Francis</pub><pmid>27386162</pmid><doi>10.1080/21623945.2016.1148834</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2162-3945
ispartof Adipocyte, 2016-04, Vol.5 (2), p.224-231
issn 2162-3945
2162-397X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4916886
source Taylor & Francis Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Brief Report
title Wnt inhibition enhances browning of mouse primary white adipocytes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A08%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wnt%20inhibition%20enhances%20browning%20of%20mouse%20primary%20white%20adipocytes&rft.jtitle=Adipocyte&rft.au=Lo,%20Kinyui%20Alice&rft.date=2016-04-02&rft.volume=5&rft.issue=2&rft.spage=224&rft.epage=231&rft.pages=224-231&rft.issn=2162-3945&rft.eissn=2162-397X&rft_id=info:doi/10.1080/21623945.2016.1148834&rft_dat=%3Cproquest_pubme%3E1802738021%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1802738021&rft_id=info:pmid/27386162&rfr_iscdi=true