Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition

Understanding enzymatic Diels–Alder (DA) reactions that can form complex natural product scaffolds is of considerable interest. Sch 210972 1, a potential anti‐HIV fungal natural product, contains a decalin core that is proposed to form through a DA reaction. We identified the gene cluster responsibl...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2015-11, Vol.16 (16), p.2294-2298
Hauptverfasser:	Sato, Michio, Yagishita, Fumitoshi, Mino, Takashi, Uchiyama, Nahoko, Patel, Ashay, Chooi, Yit-Heng, Goda, Yukihiro, Xu, Wei, Noguchi, Hiroshi, Yamamoto, Tsuyoshi, Hotta, Kinya, Houk, Kendall N., Tang, Yi, Watanabe, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus nidulans - enzymology Aspergillus nidulans - genetics cycloaddition Cycloaddition Reaction decalin density functional calculations fungal metabolite Fungal Proteins - genetics Fungal Proteins - metabolism Lipocalins - chemistry Lipocalins - metabolism Molecular Conformation Naphthalenes - chemical synthesis Naphthalenes - chemistry Natural products Stereoisomerism tetramic acid Thermodynamics
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