Factors influencing immunologic response to hepatitis B vaccine in adults
Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of va...
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| Veröffentlicht in: | Scientific reports 2016-06, Vol.6 (1), p.27251-27251, Article 27251 |
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| creator | Yang, Shigui Tian, Guo Cui, Yuanxia Ding, Cheng Deng, Min Yu, Chengbo Xu, Kaijin Ren, Jingjing Yao, Jun Li, Yiping Cao, Qing Chen, Ping Xie, Tiansheng Wang, Chencheng Wang, Bing Mao, Chen Ruan, Bing Jiang, Tian’an Li, Lanjuan |
| description | Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended. |
| doi_str_mv | 10.1038/srep27251 |
| format | Article |
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This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep27251</identifier><identifier>PMID: 27324884</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/254 ; 631/250/255/234/2513/1549 ; Adult ; Adults ; Age ; Aged ; Alcohol Drinking - immunology ; Antibodies ; Body mass index ; Female ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - immunology ; Hepatitis B - prevention & control ; Hepatitis B - virology ; Hepatitis B Vaccines - immunology ; Hepatitis B Vaccines - therapeutic use ; Hepatitis B virus - immunology ; Hepatitis B virus - pathogenicity ; Humanities and Social Sciences ; Humans ; Immunity, Innate ; Immunization ; Infections ; Infectious diseases ; Liver cirrhosis ; Male ; Middle Aged ; multidisciplinary ; Regression Analysis ; Science ; Science (multidisciplinary) ; Vaccination ; Vaccines</subject><ispartof>Scientific reports, 2016-06, Vol.6 (1), p.27251-27251, Article 27251</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-50b8ba65d441a715e2cf8d87528cf2ab19cd63f9b339002096db69ecabce02de3</citedby><cites>FETCH-LOGICAL-c438t-50b8ba65d441a715e2cf8d87528cf2ab19cd63f9b339002096db69ecabce02de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914839/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914839/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27324884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Shigui</creatorcontrib><creatorcontrib>Tian, Guo</creatorcontrib><creatorcontrib>Cui, Yuanxia</creatorcontrib><creatorcontrib>Ding, Cheng</creatorcontrib><creatorcontrib>Deng, Min</creatorcontrib><creatorcontrib>Yu, Chengbo</creatorcontrib><creatorcontrib>Xu, Kaijin</creatorcontrib><creatorcontrib>Ren, Jingjing</creatorcontrib><creatorcontrib>Yao, Jun</creatorcontrib><creatorcontrib>Li, Yiping</creatorcontrib><creatorcontrib>Cao, Qing</creatorcontrib><creatorcontrib>Chen, Ping</creatorcontrib><creatorcontrib>Xie, Tiansheng</creatorcontrib><creatorcontrib>Wang, Chencheng</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Mao, Chen</creatorcontrib><creatorcontrib>Ruan, Bing</creatorcontrib><creatorcontrib>Jiang, Tian’an</creatorcontrib><creatorcontrib>Li, Lanjuan</creatorcontrib><title>Factors influencing immunologic response to hepatitis B vaccine in adults</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.</description><subject>631/250/254</subject><subject>631/250/255/234/2513/1549</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Alcohol Drinking - immunology</subject><subject>Antibodies</subject><subject>Body mass index</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>Hepatitis B Vaccines - therapeutic use</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - pathogenicity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunization</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Regression Analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkUtLxDAUhYMojugs_ANScKPCaF5tk42g4gsEN7oOaXo7E2mTmrSC_97IjMOod5ML58u5NzkIHRJ8TjATFzFAT0uaky20RzHPZ5RRur3RT9A0xjecKqeSE7mLJrRklAvB99DjnTaDDzGzrmlHcMa6eWa7bnS-9XNrsgCx9y5CNvhsAb0e7GBjdp19aJNYSPcyXY_tEA_QTqPbCNPVuY9e725fbh5mT8_3jzdXTzPDmRhmOa5EpYu85pzokuRATSNqUeZUmIbqikhTF6yRFWMSY4plUVeFBKMrA5jWwPbR5dK3H6sOagNuCLpVfbCdDp_Ka6t-K84u1Nx_KC4JF0wmg5OVQfDvI8RBdTYaaFvtwI9RkVIKKdPHsYQe_0Hf_Bhcep4iAmPCGRdFok6XlAk-pjia9TIEq--M1DqjxB5tbr8mfxJJwNkSiElycwgbI_-5fQGf6JwC</recordid><startdate>20160621</startdate><enddate>20160621</enddate><creator>Yang, Shigui</creator><creator>Tian, Guo</creator><creator>Cui, Yuanxia</creator><creator>Ding, Cheng</creator><creator>Deng, Min</creator><creator>Yu, Chengbo</creator><creator>Xu, Kaijin</creator><creator>Ren, Jingjing</creator><creator>Yao, Jun</creator><creator>Li, Yiping</creator><creator>Cao, Qing</creator><creator>Chen, Ping</creator><creator>Xie, Tiansheng</creator><creator>Wang, Chencheng</creator><creator>Wang, Bing</creator><creator>Mao, Chen</creator><creator>Ruan, Bing</creator><creator>Jiang, Tian’an</creator><creator>Li, Lanjuan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160621</creationdate><title>Factors influencing immunologic response to hepatitis B vaccine in adults</title><author>Yang, Shigui ; Tian, Guo ; Cui, Yuanxia ; Ding, Cheng ; Deng, Min ; Yu, Chengbo ; Xu, Kaijin ; Ren, Jingjing ; Yao, Jun ; Li, Yiping ; Cao, Qing ; Chen, Ping ; Xie, Tiansheng ; Wang, Chencheng ; Wang, Bing ; Mao, Chen ; Ruan, Bing ; Jiang, Tian’an ; Li, Lanjuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-50b8ba65d441a715e2cf8d87528cf2ab19cd63f9b339002096db69ecabce02de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/250/254</topic><topic>631/250/255/234/2513/1549</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Alcohol Drinking - immunology</topic><topic>Antibodies</topic><topic>Body mass index</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B Vaccines - immunology</topic><topic>Hepatitis B Vaccines - therapeutic use</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - pathogenicity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Immunization</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Liver cirrhosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Regression Analysis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shigui</creatorcontrib><creatorcontrib>Tian, Guo</creatorcontrib><creatorcontrib>Cui, Yuanxia</creatorcontrib><creatorcontrib>Ding, Cheng</creatorcontrib><creatorcontrib>Deng, Min</creatorcontrib><creatorcontrib>Yu, Chengbo</creatorcontrib><creatorcontrib>Xu, Kaijin</creatorcontrib><creatorcontrib>Ren, Jingjing</creatorcontrib><creatorcontrib>Yao, Jun</creatorcontrib><creatorcontrib>Li, Yiping</creatorcontrib><creatorcontrib>Cao, Qing</creatorcontrib><creatorcontrib>Chen, Ping</creatorcontrib><creatorcontrib>Xie, Tiansheng</creatorcontrib><creatorcontrib>Wang, Chencheng</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Mao, Chen</creatorcontrib><creatorcontrib>Ruan, Bing</creatorcontrib><creatorcontrib>Jiang, Tian’an</creatorcontrib><creatorcontrib>Li, Lanjuan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shigui</au><au>Tian, Guo</au><au>Cui, Yuanxia</au><au>Ding, Cheng</au><au>Deng, Min</au><au>Yu, Chengbo</au><au>Xu, Kaijin</au><au>Ren, Jingjing</au><au>Yao, Jun</au><au>Li, Yiping</au><au>Cao, Qing</au><au>Chen, Ping</au><au>Xie, Tiansheng</au><au>Wang, Chencheng</au><au>Wang, Bing</au><au>Mao, Chen</au><au>Ruan, Bing</au><au>Jiang, Tian’an</au><au>Li, Lanjuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors influencing immunologic response to hepatitis B vaccine in adults</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-06-21</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>27251</spage><epage>27251</epage><pages>27251-27251</pages><artnum>27251</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27324884</pmid><doi>10.1038/srep27251</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/254 631/250/255/234/2513/1549 Adult Adults Age Aged Alcohol Drinking - immunology Antibodies Body mass index Female Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B - virology Hepatitis B Vaccines - immunology Hepatitis B Vaccines - therapeutic use Hepatitis B virus - immunology Hepatitis B virus - pathogenicity Humanities and Social Sciences Humans Immunity, Innate Immunization Infections Infectious diseases Liver cirrhosis Male Middle Aged multidisciplinary Regression Analysis Science Science (multidisciplinary) Vaccination Vaccines |
| title | Factors influencing immunologic response to hepatitis B vaccine in adults |
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