New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan
We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). H...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2016-07, Vol.60 (7), p.4339-4341 |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Nakayama, Shu-Ichi Shimuta, Ken Furubayashi, Kei-Ichi Kawahata, Takuya Unemo, Magnus Ohnishi, Makoto |
| description | We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread. |
| doi_str_mv | 10.1128/AAC.00504-16 |
| format | Article |
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FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00504-16</identifier><identifier>PMID: 27067334</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - genetics ; Ceftriaxone ; Ceftriaxone - pharmacology ; Drug Resistance, Multiple, Bacterial - genetics ; Japan ; Mechanisms of Resistance ; Microbial Sensitivity Tests ; Neisseria gonorrhoeae ; Neisseria gonorrhoeae - drug effects ; Neisseria gonorrhoeae - genetics ; Penicillin-Binding Proteins ; Penicillin-Binding Proteins - genetics</subject><ispartof>Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.4339-4341</ispartof><rights>Copyright © 2016, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2016, American Society for Microbiology. All Rights Reserved. 2016 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a451t-5c7ba9c9c9aa6bbd3afd60e262a1442510f5ddc94f05036b416a68d9aebbbbf53</citedby><cites>FETCH-LOGICAL-a451t-5c7ba9c9c9aa6bbd3afd60e262a1442510f5ddc94f05036b416a68d9aebbbbf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914677/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914677/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27067334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakayama, Shu-Ichi</creatorcontrib><creatorcontrib>Shimuta, Ken</creatorcontrib><creatorcontrib>Furubayashi, Kei-Ichi</creatorcontrib><creatorcontrib>Kawahata, Takuya</creatorcontrib><creatorcontrib>Unemo, Magnus</creatorcontrib><creatorcontrib>Ohnishi, Makoto</creatorcontrib><title>New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Ceftriaxone</subject><subject>Ceftriaxone - pharmacology</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Japan</subject><subject>Mechanisms of Resistance</subject><subject>Microbial Sensitivity Tests</subject><subject>Neisseria gonorrhoeae</subject><subject>Neisseria gonorrhoeae - drug effects</subject><subject>Neisseria gonorrhoeae - genetics</subject><subject>Penicillin-Binding Proteins</subject><subject>Penicillin-Binding Proteins - genetics</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFPFDEUxhuCgRW5cTY9YuJgO9PpTC8mm40iBtZE5dy8mb7ZLZlt17YD-t9TXCRyMLE9NC_95cv3vY-QE87OOC_bd_P54oyxmomCyz0y40y1hayV3CczxqQsRMvEIXkZ4w3Lc63YATksGyabqhIzMi3xji5wSMHCT--woOAMvZrGZE2YVsVXjDYmcIku0caIGaMr73wIa4-A9FsKYB29s2lNgS79LY70ykewPd2im9NzdEgvoh8hoaGZ_AxbcK_IiwHGiMeP7xG5_vjh--JTcfnl_GIxvyxA1DwVdd90oPp8AWTXmQoGIxmWsgQuRFlzNtTG9EoMOX8lO8ElyNYowC6foa6OyPud7nbqNmh6dNnuqLfBbiD80h6sfv7j7Fqv_K0WigvZNFng9FEg-B8TxqQ3NvY4juDQT1HzlrUNz0b-A21Uq1TVtCKjb3doH3yMAYcnR5zph1J1LlX_LlVzmfE3OxziptQ3fgouL-1f7Ou_Ez8J_2m8ugdzW6tH</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Nakayama, Shu-Ichi</creator><creator>Shimuta, Ken</creator><creator>Furubayashi, Kei-Ichi</creator><creator>Kawahata, Takuya</creator><creator>Unemo, Magnus</creator><creator>Ohnishi, Makoto</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20160701</creationdate><title>New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan</title><author>Nakayama, Shu-Ichi ; Shimuta, Ken ; Furubayashi, Kei-Ichi ; Kawahata, Takuya ; Unemo, Magnus ; Ohnishi, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a451t-5c7ba9c9c9aa6bbd3afd60e262a1442510f5ddc94f05036b416a68d9aebbbbf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anti-Bacterial Agents</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Proteins - genetics</topic><topic>Ceftriaxone</topic><topic>Ceftriaxone - pharmacology</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Japan</topic><topic>Mechanisms of Resistance</topic><topic>Microbial Sensitivity Tests</topic><topic>Neisseria gonorrhoeae</topic><topic>Neisseria gonorrhoeae - drug effects</topic><topic>Neisseria gonorrhoeae - genetics</topic><topic>Penicillin-Binding Proteins</topic><topic>Penicillin-Binding Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Shu-Ichi</creatorcontrib><creatorcontrib>Shimuta, Ken</creatorcontrib><creatorcontrib>Furubayashi, Kei-Ichi</creatorcontrib><creatorcontrib>Kawahata, Takuya</creatorcontrib><creatorcontrib>Unemo, Magnus</creatorcontrib><creatorcontrib>Ohnishi, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Shu-Ichi</au><au>Shimuta, Ken</au><au>Furubayashi, Kei-Ichi</au><au>Kawahata, Takuya</au><au>Unemo, Magnus</au><au>Ohnishi, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>60</volume><issue>7</issue><spage>4339</spage><epage>4341</epage><pages>4339-4341</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>27067334</pmid><doi>10.1128/AAC.00504-16</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Ceftriaxone Ceftriaxone - pharmacology Drug Resistance, Multiple, Bacterial - genetics Japan Mechanisms of Resistance Microbial Sensitivity Tests Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Penicillin-Binding Proteins Penicillin-Binding Proteins - genetics |
| title | New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan |
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