Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling

Abstract Background Endothelial dysfunction contributes to cardiovascular disease in diabetes mellitus. Autophagy is a multistep mechanism for the removal of damaged proteins and organelles from the cell. Under diabetic conditions, inadequate autophagy promotes cellular dysfunction and insulin resis...

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Veröffentlicht in:	Atherosclerosis 2016-04, Vol.247, p.207-217
Hauptverfasser:	Fetterman, Jessica L, Holbrook, Monica, Flint, Nir, Feng, Bihua, Bretόn-Romero, Rosa, Linder, Erika A, Berk, Brittany D, Duess, Mai-Ann, Farb, Melissa G, Gokce, Noyan, Shirihai, Orian S, Hamburg, Naomi M, Vita, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adult Aged Autophagy Autophagy - drug effects Biomarkers - metabolism Cardiovascular Case-Control Studies Cell Separation - methods Cells, Cultured Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - blood Diabetic Angiopathies - pathology Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Female Humans Macrolides - pharmacology Male Middle Aged Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Signal Transduction - drug effects Spermidine - pharmacology
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