Reduced motor neuron excitability is an important contributor to weakness in a rat model of sepsis

The mechanisms by which sepsis triggers intensive care unit acquired weakness (ICUAW) remain unclear. We previously identified difficulty with motor unit recruitment in patients as a novel contributor to ICUAW. To study the mechanism underlying poor recruitment of motor units we used the rat cecal l...

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Veröffentlicht in:	Experimental neurology 2016-08, Vol.282, p.1-8
Hauptverfasser:	Nardelli, Paul, Vincent, Jacob A., Powers, Randall, Cope, Tim C., Rich, Mark M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Analysis of Variance Animals Critical illness Disease Models, Animal Electric Stimulation Electromyography ICU acquired weakness Motoneuron Motor Neurons - physiology Motor unit Muscle Muscle Weakness - etiology Muscle Weakness - pathology Myopathy Nerve Neuromuscular junction Neuropathy Patch-Clamp Techniques Rats Sepsis Sepsis - complications Spinal Cord - pathology Synaptic Transmission - physiology
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