IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance

Candida spp. elicit cytokine production downstream of various pathogen recognition receptors, including C-type lectin-like receptors, TLRs, and nucleotide oligomerization domain (NOD)-like receptors. IL-12 family members IL-12p70 and IL-23 are important for host immunity against Candida spp. In this...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-07, Vol.197 (1), p.208-221
Hauptverfasser:	Patin, Emmanuel C, Jones, Adam V, Thompson, Aiysha, Clement, Mathew, Liao, Chia-Te, Griffiths, James S, Wallace, Leah E, Bryant, Clare E, Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R, Taylor, Philip R, Jones, Gareth W, Orr, Selinda J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Candida Candida - physiology Candidiasis - immunology Cells, Cultured Cytokines - metabolism Immune Evasion Infectious Disease and Host Response Inflammation Mediators - metabolism Interferon-beta - metabolism Interleukin-27 - genetics Interleukin-27 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myeloid Cells - immunology Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Receptors, Cytokine - genetics Receptors, Interleukin Signal Transduction Toll-Like Receptor 7 - metabolism
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