Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction

We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on COX2/PGE2 and filaggrin. PMs induced increase...

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Veröffentlicht in:	Scientific reports 2016-06, Vol.6 (1), p.27995-27995, Article 27995
Hauptverfasser:	Lee, Chiang-Wen, Lin, Zih-Chan, Hu, Stephen Chu-Sung, Chiang, Yao-Chang, Hsu, Lee-Fen, Lin, Yu-Ching, Lee, I-Ta, Tsai, Ming-Horng, Fang, Jia-You
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 38/1 38/22 38/90 42/89 631/80/304 692/420/256/2515 82/80 96/109 96/31 96/95 Animals Antioxidants - pharmacology Cell Line Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cytokines Dermatology Dinoprostone - metabolism Down-Regulation - drug effects Drug dosages Hospitals Humanities and Social Sciences Humans Intermediate Filament Proteins - metabolism Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Male Medicine Mice Mice, Inbred BALB C Mice, Nude multidisciplinary NADPH Oxidase 2 - antagonists & inhibitors NADPH Oxidase 2 - genetics NADPH Oxidase 2 - metabolism Particulate Matter - toxicity Phosphorylation - drug effects Proteins Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Prostaglandin E - antagonists & inhibitors Science Signal Transduction - drug effects Skin Skin - drug effects
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