A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?
The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribut...
Gespeichert in:
| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-02, Vol.35 (2), p.303-308 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 308 |
|---|---|
| container_issue | 2 |
| container_start_page | 303 |
| container_title | Arteriosclerosis, thrombosis, and vascular biology |
| container_volume | 35 |
| creator | Welch-Reardon, Katrina M Wu, Nan Hughes, Christopher C.W |
| description | The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribute to heart valve formation and the generation of cancer-associated fibroblasts. During angiogenic sprouting, endothelial cells express many of the same genes and break down basement membrane; however, they retain intercellular junctions and migrate as a connected train of cells rather than as individual cells. This has been termed a partial endothelial-to-mesenchymal transition. A key regulatory check-point determines whether cells undergo a full or a partial epithelial-to-mesenchymal transitions/endothelial-to-mesenchymal transition; however, very little is known about how this switch is controlled. Here we discuss these developmental/pathological pathways, with a particular focus on their role in vascular biology. |
| doi_str_mv | 10.1161/ATVBAHA.114.303220 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4911209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652412368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6340-75289f13ab1dae29b34d844ed13b59a8f68838118af5e629114eb42951f82d273</originalsourceid><addsrcrecordid>eNp9kc9OGzEQxi1UVCjtC3BAe-xlqf-t471QLVFKIqUCVYGr5d2dzRocG-wNiBvv0Dfsk9QoIaKXnmZG883PnvkQOib4lBBBvlWLm_NqWqWCnzLMKMV76JAUlOdcMPEh5XhU5oXg9AB9ivEWY8yT6CM6oAWnhSDlIZpV2S9vIet8yK50GIy22cS1fujBpvzPy--fEME1_fMqdRZBu2gG413MjMsqtzR-CQ6iid8_o_1O2whftvEIXf-YLMbTfH55MRtX87wRjON8VFBZdoTpmrQaaFkz3krOoSWsLkotOyElk4RI3RUgaJmWg5rTsiCdpC0dsSN0tuHer-sVtA24IWir7oNZ6fCsvDbq344zvVr6R8UTi-IyAb5uAcE_rCEOamViA9ZqB34dFRHphIQyIZOUbqRN8DEG6HbPEKxePVBbD1LB1caDNHTy_oO7kbejJ4HYCJ68HSDEO7t-gqB60Hbo_0f-C4tqlLk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652412368</pqid></control><display><type>article</type><title>A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Welch-Reardon, Katrina M ; Wu, Nan ; Hughes, Christopher C.W</creator><creatorcontrib>Welch-Reardon, Katrina M ; Wu, Nan ; Hughes, Christopher C.W</creatorcontrib><description>The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribute to heart valve formation and the generation of cancer-associated fibroblasts. During angiogenic sprouting, endothelial cells express many of the same genes and break down basement membrane; however, they retain intercellular junctions and migrate as a connected train of cells rather than as individual cells. This has been termed a partial endothelial-to-mesenchymal transition. A key regulatory check-point determines whether cells undergo a full or a partial epithelial-to-mesenchymal transitions/endothelial-to-mesenchymal transition; however, very little is known about how this switch is controlled. Here we discuss these developmental/pathological pathways, with a particular focus on their role in vascular biology.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.114.303220</identifier><identifier>PMID: 25425619</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Angiogenic Proteins - metabolism ; Animals ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Epithelial-Mesenchymal Transition ; Humans ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Signal Transduction ; Transcription Factors - metabolism</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2015-02, Vol.35 (2), p.303-308</ispartof><rights>2015 American Heart Association, Inc.</rights><rights>2014 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6340-75289f13ab1dae29b34d844ed13b59a8f68838118af5e629114eb42951f82d273</citedby><cites>FETCH-LOGICAL-c6340-75289f13ab1dae29b34d844ed13b59a8f68838118af5e629114eb42951f82d273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25425619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Welch-Reardon, Katrina M</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Hughes, Christopher C.W</creatorcontrib><title>A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribute to heart valve formation and the generation of cancer-associated fibroblasts. During angiogenic sprouting, endothelial cells express many of the same genes and break down basement membrane; however, they retain intercellular junctions and migrate as a connected train of cells rather than as individual cells. This has been termed a partial endothelial-to-mesenchymal transition. A key regulatory check-point determines whether cells undergo a full or a partial epithelial-to-mesenchymal transitions/endothelial-to-mesenchymal transition; however, very little is known about how this switch is controlled. Here we discuss these developmental/pathological pathways, with a particular focus on their role in vascular biology.</description><subject>Angiogenic Proteins - metabolism</subject><subject>Animals</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Humans</subject><subject>Neovascularization, Pathologic</subject><subject>Neovascularization, Physiologic</subject><subject>Signal Transduction</subject><subject>Transcription Factors - metabolism</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9OGzEQxi1UVCjtC3BAe-xlqf-t471QLVFKIqUCVYGr5d2dzRocG-wNiBvv0Dfsk9QoIaKXnmZG883PnvkQOib4lBBBvlWLm_NqWqWCnzLMKMV76JAUlOdcMPEh5XhU5oXg9AB9ivEWY8yT6CM6oAWnhSDlIZpV2S9vIet8yK50GIy22cS1fujBpvzPy--fEME1_fMqdRZBu2gG413MjMsqtzR-CQ6iid8_o_1O2whftvEIXf-YLMbTfH55MRtX87wRjON8VFBZdoTpmrQaaFkz3krOoSWsLkotOyElk4RI3RUgaJmWg5rTsiCdpC0dsSN0tuHer-sVtA24IWir7oNZ6fCsvDbq344zvVr6R8UTi-IyAb5uAcE_rCEOamViA9ZqB34dFRHphIQyIZOUbqRN8DEG6HbPEKxePVBbD1LB1caDNHTy_oO7kbejJ4HYCJ68HSDEO7t-gqB60Hbo_0f-C4tqlLk</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Welch-Reardon, Katrina M</creator><creator>Wu, Nan</creator><creator>Hughes, Christopher C.W</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201502</creationdate><title>A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?</title><author>Welch-Reardon, Katrina M ; Wu, Nan ; Hughes, Christopher C.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6340-75289f13ab1dae29b34d844ed13b59a8f68838118af5e629114eb42951f82d273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Angiogenic Proteins - metabolism</topic><topic>Animals</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - pathology</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Humans</topic><topic>Neovascularization, Pathologic</topic><topic>Neovascularization, Physiologic</topic><topic>Signal Transduction</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Welch-Reardon, Katrina M</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Hughes, Christopher C.W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Welch-Reardon, Katrina M</au><au>Wu, Nan</au><au>Hughes, Christopher C.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2015-02</date><risdate>2015</risdate><volume>35</volume><issue>2</issue><spage>303</spage><epage>308</epage><pages>303-308</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><abstract>The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a parallel process, governed by a similar set of signaling and transcription factors, endothelial-to-mesenchymal transitions (EndoMT) contribute to heart valve formation and the generation of cancer-associated fibroblasts. During angiogenic sprouting, endothelial cells express many of the same genes and break down basement membrane; however, they retain intercellular junctions and migrate as a connected train of cells rather than as individual cells. This has been termed a partial endothelial-to-mesenchymal transition. A key regulatory check-point determines whether cells undergo a full or a partial epithelial-to-mesenchymal transitions/endothelial-to-mesenchymal transition; however, very little is known about how this switch is controlled. Here we discuss these developmental/pathological pathways, with a particular focus on their role in vascular biology.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>25425619</pmid><doi>10.1161/ATVBAHA.114.303220</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2015-02, Vol.35 (2), p.303-308 |
| issn | 1079-5642 1524-4636 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4911209 |
| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Angiogenic Proteins - metabolism Animals Endothelial Cells - metabolism Endothelial Cells - pathology Epithelial-Mesenchymal Transition Humans Neovascularization, Pathologic Neovascularization, Physiologic Signal Transduction Transcription Factors - metabolism |
| title | A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A19%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Role%20for%20Partial%20Endothelial%E2%80%93Mesenchymal%20Transitions%20in%20Angiogenesis?&rft.jtitle=Arteriosclerosis,%20thrombosis,%20and%20vascular%20biology&rft.au=Welch-Reardon,%20Katrina%20M&rft.date=2015-02&rft.volume=35&rft.issue=2&rft.spage=303&rft.epage=308&rft.pages=303-308&rft.issn=1079-5642&rft.eissn=1524-4636&rft_id=info:doi/10.1161/ATVBAHA.114.303220&rft_dat=%3Cproquest_pubme%3E1652412368%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652412368&rft_id=info:pmid/25425619&rfr_iscdi=true |