sMICA as novel and early predictors for acute myocardial infarction
MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form (sM...
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| Veröffentlicht in: | European journal of medical research 2016-06, Vol.21 (1), p.25-25, Article 25 |
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| creator | Fu, Cunyu Shi, Yunxiang Yao, Zongqin |
| description | MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form (sMICA). In the present study, we designed to investigate the serum sMICA level in patients with AMI and determine whether sMICA could be an early biomarker for diagnosis of AMI.
There were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.
Serum levels of sMICA reach the peaks [(1.34 ± .18 and 1.72 ± .20)n/l] at 6-12 h and serum levels of cTnT reach the peaks [(1.16 ± .28 and 1.14 ± .34)n/l] at 12-24 h. Both of them were significantly higher than the healthy controls [(.168 ± .014) n/l, p = .000] for sMICA and [(.13 ± .06) n/l, p = .000] for Troponin T (cTnT). sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 (95 % CI .69-.83) in discriminating AMI patients from healthy controls.
We have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans. |
| doi_str_mv | 10.1186/s40001-016-0220-2 |
| format | Article |
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There were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.
Serum levels of sMICA reach the peaks [(1.34 ± .18 and 1.72 ± .20)n/l] at 6-12 h and serum levels of cTnT reach the peaks [(1.16 ± .28 and 1.14 ± .34)n/l] at 12-24 h. Both of them were significantly higher than the healthy controls [(.168 ± .014) n/l, p = .000] for sMICA and [(.13 ± .06) n/l, p = .000] for Troponin T (cTnT). sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 (95 % CI .69-.83) in discriminating AMI patients from healthy controls.
We have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans.</description><identifier>ISSN: 2047-783X</identifier><identifier>ISSN: 0949-2321</identifier><identifier>EISSN: 2047-783X</identifier><identifier>DOI: 10.1186/s40001-016-0220-2</identifier><identifier>PMID: 27306684</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Biological markers ; Biomarkers - blood ; Care and treatment ; Case-Control Studies ; Coronary heart disease ; Diagnosis ; Early Diagnosis ; Female ; Follow-Up Studies ; Heart attack ; Histocompatibility Antigens Class I - blood ; Histocompatibility testing ; Humans ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Prognosis ; Risk factors</subject><ispartof>European journal of medical research, 2016-06, Vol.21 (1), p.25-25, Article 25</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-14f9e06ba5ee3161ea180c69d0a5780eed1e5bdca0232e8c081b098b7a4d1aaf3</citedby><cites>FETCH-LOGICAL-c525t-14f9e06ba5ee3161ea180c69d0a5780eed1e5bdca0232e8c081b098b7a4d1aaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910230/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910230/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27306684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Cunyu</creatorcontrib><creatorcontrib>Shi, Yunxiang</creatorcontrib><creatorcontrib>Yao, Zongqin</creatorcontrib><title>sMICA as novel and early predictors for acute myocardial infarction</title><title>European journal of medical research</title><addtitle>Eur J Med Res</addtitle><description>MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form (sMICA). In the present study, we designed to investigate the serum sMICA level in patients with AMI and determine whether sMICA could be an early biomarker for diagnosis of AMI.
There were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.
Serum levels of sMICA reach the peaks [(1.34 ± .18 and 1.72 ± .20)n/l] at 6-12 h and serum levels of cTnT reach the peaks [(1.16 ± .28 and 1.14 ± .34)n/l] at 12-24 h. Both of them were significantly higher than the healthy controls [(.168 ± .014) n/l, p = .000] for sMICA and [(.13 ± .06) n/l, p = .000] for Troponin T (cTnT). sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 (95 % CI .69-.83) in discriminating AMI patients from healthy controls.
We have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans.</description><subject>Biological markers</subject><subject>Biomarkers - blood</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Coronary heart disease</subject><subject>Diagnosis</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attack</subject><subject>Histocompatibility Antigens Class I - blood</subject><subject>Histocompatibility testing</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Prognosis</subject><subject>Risk factors</subject><issn>2047-783X</issn><issn>0949-2321</issn><issn>2047-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptks1q3DAUhU1paEKaB-imGAqlG6dXsizJm0IY0h9IySaB7sS1fJ1RkK2pZAfm7ath0jBTihYS0neOpMMpincMLhnT8nMSAMAqYLICzqHir4ozDkJVSte_Xh-sT4uLlB4zDJJL1bZvilOuapBSi7NilX7-WF2VmMopPJEvcepLwui35SZS7-wcYiqHEEu0y0zluA0WY-_Ql24aMNrZheltcTKgT3TxPJ8X91-v71bfq5vbb9n8prINb-aKiaElkB02RDWTjJBpsLLtARulgahn1HS9ReA1J21Bsw5a3SkUPUMc6vPiy953s3Qj9ZamOaI3m-hGjFsT0Jnjk8mtzUN4MqJl2ROywadngxh-L5RmM7pkyXucKCzJMNUqrWQj64x--Ad9DEuc8vdMfjVoIRp1QD2gJ5MTCfleuzM1V0IyrZhQKlOX_6Hy6Gl0Nkw0uLx_JPh4IFgT-nmdgl92YadjkO1BG0NKkYaXMBiYXUvMviUmt8TsWmJ41rw_TPFF8bcT9R-xV7Wi</recordid><startdate>20160616</startdate><enddate>20160616</enddate><creator>Fu, Cunyu</creator><creator>Shi, Yunxiang</creator><creator>Yao, Zongqin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160616</creationdate><title>sMICA as novel and early predictors for acute myocardial infarction</title><author>Fu, Cunyu ; Shi, Yunxiang ; Yao, Zongqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-14f9e06ba5ee3161ea180c69d0a5780eed1e5bdca0232e8c081b098b7a4d1aaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biological markers</topic><topic>Biomarkers - blood</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Coronary heart disease</topic><topic>Diagnosis</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart attack</topic><topic>Histocompatibility Antigens Class I - blood</topic><topic>Histocompatibility testing</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Prognosis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Cunyu</creatorcontrib><creatorcontrib>Shi, Yunxiang</creatorcontrib><creatorcontrib>Yao, Zongqin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Cunyu</au><au>Shi, Yunxiang</au><au>Yao, Zongqin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>sMICA as novel and early predictors for acute myocardial infarction</atitle><jtitle>European journal of medical research</jtitle><addtitle>Eur J Med Res</addtitle><date>2016-06-16</date><risdate>2016</risdate><volume>21</volume><issue>1</issue><spage>25</spage><epage>25</epage><pages>25-25</pages><artnum>25</artnum><issn>2047-783X</issn><issn>0949-2321</issn><eissn>2047-783X</eissn><abstract>MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form (sMICA). In the present study, we designed to investigate the serum sMICA level in patients with AMI and determine whether sMICA could be an early biomarker for diagnosis of AMI.
There were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.
Serum levels of sMICA reach the peaks [(1.34 ± .18 and 1.72 ± .20)n/l] at 6-12 h and serum levels of cTnT reach the peaks [(1.16 ± .28 and 1.14 ± .34)n/l] at 12-24 h. Both of them were significantly higher than the healthy controls [(.168 ± .014) n/l, p = .000] for sMICA and [(.13 ± .06) n/l, p = .000] for Troponin T (cTnT). sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 (95 % CI .69-.83) in discriminating AMI patients from healthy controls.
We have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27306684</pmid><doi>10.1186/s40001-016-0220-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Biological markers Biomarkers - blood Care and treatment Case-Control Studies Coronary heart disease Diagnosis Early Diagnosis Female Follow-Up Studies Heart attack Histocompatibility Antigens Class I - blood Histocompatibility testing Humans Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - diagnosis Prognosis Risk factors |
| title | sMICA as novel and early predictors for acute myocardial infarction |
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