Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam
Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based...
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| Veröffentlicht in: | Scientific reports 2016-06, Vol.6 (1), p.27856-27856, Article 27856 |
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| creator | Yoshihara, Keisuke Le, Minh Nhat Okamoto, Michiko Wadagni, Anita Carolle Akpeedje Nguyen, Hien Anh Toizumi, Michiko Pham, Enga Suzuki, Motoi Nguyen, Ai Thi Thuy Oshitani, Hitoshi Ariyoshi, Koya Moriuchi, Hiroyuki Hashizume, Masahiro Dang, Duc Anh Yoshida, Lay-Myint |
| description | Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1. |
| doi_str_mv | 10.1038/srep27856 |
| format | Article |
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To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep27856</identifier><identifier>PMID: 27306333</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/308/3187 ; Genotype & phenotype ; Genotypes ; Hospitalization ; Humanities and Social Sciences ; Infections ; multidisciplinary ; Multivariate analysis ; Pathogens ; Pediatrics ; Population ; Proteins ; Respiratory syncytial virus ; Respiratory tract ; Science ; Science (multidisciplinary) ; Statistical analysis</subject><ispartof>Scientific reports, 2016-06, Vol.6 (1), p.27856-27856, Article 27856</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-5d985fc6c19018cefa5eab379c029c638ada72eb127a62304d5a55831fe8161f3</citedby><cites>FETCH-LOGICAL-c522t-5d985fc6c19018cefa5eab379c029c638ada72eb127a62304d5a55831fe8161f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910061/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910061/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27306333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshihara, Keisuke</creatorcontrib><creatorcontrib>Le, Minh Nhat</creatorcontrib><creatorcontrib>Okamoto, Michiko</creatorcontrib><creatorcontrib>Wadagni, Anita Carolle Akpeedje</creatorcontrib><creatorcontrib>Nguyen, Hien Anh</creatorcontrib><creatorcontrib>Toizumi, Michiko</creatorcontrib><creatorcontrib>Pham, Enga</creatorcontrib><creatorcontrib>Suzuki, Motoi</creatorcontrib><creatorcontrib>Nguyen, Ai Thi Thuy</creatorcontrib><creatorcontrib>Oshitani, Hitoshi</creatorcontrib><creatorcontrib>Ariyoshi, Koya</creatorcontrib><creatorcontrib>Moriuchi, Hiroyuki</creatorcontrib><creatorcontrib>Hashizume, Masahiro</creatorcontrib><creatorcontrib>Dang, Duc Anh</creatorcontrib><creatorcontrib>Yoshida, Lay-Myint</creatorcontrib><title>Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.</description><subject>692/308/174</subject><subject>692/308/3187</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Hospitalization</subject><subject>Humanities and Social Sciences</subject><subject>Infections</subject><subject>multidisciplinary</subject><subject>Multivariate analysis</subject><subject>Pathogens</subject><subject>Pediatrics</subject><subject>Population</subject><subject>Proteins</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory tract</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Statistical 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Rep</addtitle><date>2016-06-16</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>27856</spage><epage>27856</epage><pages>27856-27856</pages><artnum>27856</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37–3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01–3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27306333</pmid><doi>10.1038/srep27856</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/174 692/308/3187 Genotype & phenotype Genotypes Hospitalization Humanities and Social Sciences Infections multidisciplinary Multivariate analysis Pathogens Pediatrics Population Proteins Respiratory syncytial virus Respiratory tract Science Science (multidisciplinary) Statistical analysis |
| title | Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam |
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