Recent developments in using mechanistic cardiac modelling for drug safety evaluation

•Modelling and simulation can streamline decision making in drug safety testing.•Computational cardiac electrophysiology is a mature technology with a long heritage.•There are many challenges and opportunities in using in silico techniques in future.•We discuss how models can be used at different st...

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Veröffentlicht in:	Drug discovery today 2016-06, Vol.21 (6), p.924-938
Hauptverfasser:	Davies, Mark R., Wang, Ken, Mirams, Gary R., Caruso, Antonello, Noble, Denis, Walz, Antje, Lavé, Thierry, Schuler, Franz, Singer, Thomas, Polonchuk, Liudmila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Computer Simulation Decision Making Drug Discovery Heart - physiology Humans Models, Biological Pharmacokinetics Review Risk Assessment
Online-Zugang:	Volltext
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