Limiting collagen turnover via collagenase‐resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension in which right ventricular (RV) afterload is increased and death typically occurs due to decompensated RV hypertrophy and failure. Collagen accumulation has been implicated in pulmonary artery remodeling, but how it aff...

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Veröffentlicht in:	Physiological reports 2016-06, Vol.4 (11), p.e12815-n/a
Hauptverfasser:	Golob, Mark J., Wang, Zhijie, Prostrollo, Anthony J., Hacker, Timothy A., Chesler, Naomi C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Cardiac energetics Cardiac function Cardiovascular Conditions, Disorders and Treatments Catheterization Collagen Collagen (type I) Collagen - genetics Collagen - metabolism Collagenase Collagenases - genetics Collagenases - metabolism Coronary vessels Echocardiography effective arterial elastance Efficiency Fibrosis Fibrosis - metabolism Fibrosis - pathology Fibrosis - physiopathology Heart Hypertension Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Hypertrophy Hypotheses Hypoxia Intubation Lung diseases Mice Mice, Transgenic Original Research Physiology Preservation pressure‐volume loop Pulmonary artery Pulmonary Circulation Pulmonary hypertension Respiratory Conditions Disorder and Diseases Structure-function relationships Trends Ventricle Ventricular Dysfunction, Right - metabolism Ventricular Dysfunction, Right - pathology Ventricular Dysfunction, Right - physiopathology
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