Validation of a rapid type 1 diabetes autoantibody screening assay for community‐based screening of organ donors to identify subjects at increased risk for the disease

Summary The Network for Pancreatic Organ donors with Diabetes (nPOD) programme was developed in response to an unmet research need for human pancreatic tissue obtained from individuals with type 1 diabetes mellitus and people at increased risk [i.e. autoantibody (AAb)‐positive] for the disease. This...

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Veröffentlicht in:	Clinical and experimental immunology 2016-07, Vol.185 (1), p.33-41
Hauptverfasser:	Wasserfall, C., Montgomery, E., Yu, L., Michels, A., Gianani, R., Pugliese, A., Nierras, C., Kaddis, J. S., Schatz, D. A., Bonifacio, E., Atkinson, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Area Under Curve autoantibodies Autoantibodies - blood Cation Transport Proteins - antagonists & inhibitors Cation Transport Proteins - genetics Cation Transport Proteins - immunology Child Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - surgery Donor Selection - standards Enzyme-Linked Immunosorbent Assay - standards Female Glutamate Decarboxylase - antagonists & inhibitors Glutamate Decarboxylase - genetics Glutamate Decarboxylase - immunology Humans Male Middle Aged nPOD organ donor Original Receptor-Like Protein Tyrosine Phosphatases, Class 8 - antagonists & inhibitors Receptor-Like Protein Tyrosine Phosphatases, Class 8 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology Risk screening Sensitivity and Specificity Tissue Donors - supply & distribution type 1 diabetes Zinc Transporter 8
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