Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4–MD2 Complex

Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect of single TLR4-MD2 inhibition by using eritoran, compared with the effect of...

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Veröffentlicht in:	The Journal of infectious diseases 2016-07, Vol.214 (1), p.140-150
Hauptverfasser:	Gustavsen, Alice, Nymo, Stig, Landsem, Anne, Christiansen, Dorte, Ryan, Liv, Husebye, Harald, Lau, Corinna, Pischke, Søren E., Lambris, John D., Espevik, Terje, Mollnes, Tom E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Cytokines - blood Escherichia Escherichia coli - drug effects Humans Inflammation - blood Inflammation - drug therapy Inflammation - etiology Inflammation - microbiology Lipopolysaccharide Receptors - blood Lipopolysaccharide Receptors - drug effects Major and Brief Reports Medical disciplines: 700 Medical immunology: 716 Medisinsk immunologi: 716 Medisinske Fag: 700 PATHOGENESIS AND HOST RESPONSE Sepsis - drug therapy Sepsis - microbiology Staphylococcal Infections - complications Staphylococcal Infections - drug therapy Staphylococcus Staphylococcus aureus - drug effects Toll-Like Receptor 4 - drug effects VDP
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