Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway
Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma. Sixty-four male...
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| Veröffentlicht in: | Frontiers in immunology 2016-06, Vol.7, p.237-237 |
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| creator | Alberca-Custódio, Ricardo Wesley Greiffo, Flávia Regina MacKenzie, BreAnne Oliveira-Junior, Manoel Carneiro Andrade-Sousa, Adilson Santos Graudenz, Gustavo Silveira Santos, Angela Batista Gomes Damaceno-Rodrigues, Nilsa Regina Castro-Faria-Neto, Hugo Caire Arantes-Costa, Fernanda Magalhaes Martins, Milton De Arruda Abbasi, Asghar Lin, Chin Jia Idzko, Marco Ligeiro Oliveira, Ana Paula Northoff, Hinnak Vieira, Rodolfo Paula |
| description | Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma.
Sixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks. Quantification of bronchoalveolar lavage (BAL) cellularity, leukocytes, airway remodeling, interleukin (IL)-5, IL-13, cysteinyl leukotriene (CysLT), and leukotriene B4 (LTB4) in BAL was performed. In addition, quantitative analyses on peribronchial leukocytes and airway epithelium for LT pathway agents: 5-lypoxygenase (5-LO), LTA4 hydrolase (LTA4H), CysLT1 receptor, CysLT2 receptor, LTC4 synthase, and LTB4 receptor 2 (BLT2) were performed. Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography.
AE decreased eosinophils (p 0.001), lymphocytes (p |
| doi_str_mv | 10.3389/fimmu.2016.00237 |
| format | Article |
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Sixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks. Quantification of bronchoalveolar lavage (BAL) cellularity, leukocytes, airway remodeling, interleukin (IL)-5, IL-13, cysteinyl leukotriene (CysLT), and leukotriene B4 (LTB4) in BAL was performed. In addition, quantitative analyses on peribronchial leukocytes and airway epithelium for LT pathway agents: 5-lypoxygenase (5-LO), LTA4 hydrolase (LTA4H), CysLT1 receptor, CysLT2 receptor, LTC4 synthase, and LTB4 receptor 2 (BLT2) were performed. Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography.
AE decreased eosinophils (p < 0.001), neutrophils (p > 0.001), lymphocytes (p < 0.001), and macrophages (p < 0.01) in BAL, as well as eosinophils (p < 0.01), lymphocytes (p < 0.001), and macrophages (p > 0.001) in airway walls. Collagen (p < 0.01), elastic fibers (p < 0.01), mucus production (p < 0.01), and smooth muscle thickness (p < 0.01), as well as IL-5 (p < 0.01), IL-13 (p < 0.01), CysLT (p < 0.01), and LTB4 (p < 0.01) in BAL were reduced. 5-LO (p < 0.05), LTA4H (p < 0.05), CysLT1 receptor (p < 0.001), CysLT2 receptor (p < 0.001), LTC4 synthase (p < 0.001), and BLT2 (p < 0.01) expression by peribronchial leukocytes and airway epithelium were reduced. Lastly, AHR to MCh 25 mg/mL (p < 0.05) and 50 mg/mL (p < 0.01) was reduced.
Moderate-intensity AE attenuated asthma phenotype and LT production in both pulmonary leukocytes and airway epithelium of OVA-treated mice.]]></description><identifier>ISSN: 1664-3224</identifier><identifier>EISSN: 1664-3224</identifier><identifier>DOI: 10.3389/fimmu.2016.00237</identifier><identifier>PMID: 27379098</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Immunology</subject><ispartof>Frontiers in immunology, 2016-06, Vol.7, p.237-237</ispartof><rights>Copyright © 2016 Alberca-Custódio, Greiffo, MacKenzie, Oliveira-Junior, Andrade-Sousa, Graudenz, Santos, Damaceno-Rodrigues, Castro-Faria-Neto, Arantes-Costa, Martins, Abbasi, Lin, Idzko, Ligeiro Oliveira, Northoff and Vieira. 2016 Alberca-Custódio, Greiffo, MacKenzie, Oliveira-Junior, Andrade-Sousa, Graudenz, Santos, Damaceno-Rodrigues, Castro-Faria-Neto, Arantes-Costa, Martins, Abbasi, Lin, Idzko, Ligeiro Oliveira, Northoff and Vieira</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-f536acb19a48f336c589ba1e005f069d1328cfa0de7a5964cb1dc4f4deb736e03</citedby><cites>FETCH-LOGICAL-c462t-f536acb19a48f336c589ba1e005f069d1328cfa0de7a5964cb1dc4f4deb736e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27379098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alberca-Custódio, Ricardo Wesley</creatorcontrib><creatorcontrib>Greiffo, Flávia Regina</creatorcontrib><creatorcontrib>MacKenzie, BreAnne</creatorcontrib><creatorcontrib>Oliveira-Junior, Manoel Carneiro</creatorcontrib><creatorcontrib>Andrade-Sousa, Adilson Santos</creatorcontrib><creatorcontrib>Graudenz, Gustavo Silveira</creatorcontrib><creatorcontrib>Santos, Angela Batista Gomes</creatorcontrib><creatorcontrib>Damaceno-Rodrigues, Nilsa Regina</creatorcontrib><creatorcontrib>Castro-Faria-Neto, Hugo Caire</creatorcontrib><creatorcontrib>Arantes-Costa, Fernanda Magalhaes</creatorcontrib><creatorcontrib>Martins, Milton De Arruda</creatorcontrib><creatorcontrib>Abbasi, Asghar</creatorcontrib><creatorcontrib>Lin, Chin Jia</creatorcontrib><creatorcontrib>Idzko, Marco</creatorcontrib><creatorcontrib>Ligeiro Oliveira, Ana Paula</creatorcontrib><creatorcontrib>Northoff, Hinnak</creatorcontrib><creatorcontrib>Vieira, Rodolfo Paula</creatorcontrib><title>Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway</title><title>Frontiers in immunology</title><addtitle>Front Immunol</addtitle><description><![CDATA[Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma.
Sixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks. Quantification of bronchoalveolar lavage (BAL) cellularity, leukocytes, airway remodeling, interleukin (IL)-5, IL-13, cysteinyl leukotriene (CysLT), and leukotriene B4 (LTB4) in BAL was performed. In addition, quantitative analyses on peribronchial leukocytes and airway epithelium for LT pathway agents: 5-lypoxygenase (5-LO), LTA4 hydrolase (LTA4H), CysLT1 receptor, CysLT2 receptor, LTC4 synthase, and LTB4 receptor 2 (BLT2) were performed. Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography.
AE decreased eosinophils (p < 0.001), neutrophils (p > 0.001), lymphocytes (p < 0.001), and macrophages (p < 0.01) in BAL, as well as eosinophils (p < 0.01), lymphocytes (p < 0.001), and macrophages (p > 0.001) in airway walls. Collagen (p < 0.01), elastic fibers (p < 0.01), mucus production (p < 0.01), and smooth muscle thickness (p < 0.01), as well as IL-5 (p < 0.01), IL-13 (p < 0.01), CysLT (p < 0.01), and LTB4 (p < 0.01) in BAL were reduced. 5-LO (p < 0.05), LTA4H (p < 0.05), CysLT1 receptor (p < 0.001), CysLT2 receptor (p < 0.001), LTC4 synthase (p < 0.001), and BLT2 (p < 0.01) expression by peribronchial leukocytes and airway epithelium were reduced. Lastly, AHR to MCh 25 mg/mL (p < 0.05) and 50 mg/mL (p < 0.01) was reduced.
Moderate-intensity AE attenuated asthma phenotype and LT production in both pulmonary leukocytes and airway epithelium of OVA-treated mice.]]></description><subject>Immunology</subject><issn>1664-3224</issn><issn>1664-3224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVUctOwzAQtBCIosKdE_KRS4sTO058QaoQL6mICsHZcpw1MSRxsR2gf09KoYK97Eo7M7uaQeg4IVNKC3FmbNv205QkfEpISvMddJBwziY0Tdnun3mEjkJ4IUMxQSnN9tEozWkuiCgO0MMMvCutxpef4LUNgB-g6jUEPAuxbhVe1NC5uFoCLlf4zlV9o6J1HXYGxxrwHPpXF72FDvBCxfpDrQ7RnlFNgKOfPkZPV5ePFzeT-f317cVsPtGMp3FiMsqVLhOhWGEo5TorRKkSICQzhIsqoWmhjSIV5CoTnA3QSjPDKihzyoHQMTrf6C77soVKQxe9auTS21b5lXTKyv-bztby2b1LJsggSAeB0x8B7956CFG2NmhoGtWB64NMCpKynGWDuWNENlDtXQgezPZMQuQ6DfmdhlynIb_TGCgnf9_bEn69p19GIIh4</recordid><startdate>20160614</startdate><enddate>20160614</enddate><creator>Alberca-Custódio, Ricardo Wesley</creator><creator>Greiffo, Flávia Regina</creator><creator>MacKenzie, BreAnne</creator><creator>Oliveira-Junior, Manoel Carneiro</creator><creator>Andrade-Sousa, Adilson Santos</creator><creator>Graudenz, Gustavo Silveira</creator><creator>Santos, Angela Batista Gomes</creator><creator>Damaceno-Rodrigues, Nilsa Regina</creator><creator>Castro-Faria-Neto, Hugo Caire</creator><creator>Arantes-Costa, Fernanda Magalhaes</creator><creator>Martins, Milton De Arruda</creator><creator>Abbasi, Asghar</creator><creator>Lin, Chin Jia</creator><creator>Idzko, Marco</creator><creator>Ligeiro Oliveira, Ana Paula</creator><creator>Northoff, Hinnak</creator><creator>Vieira, Rodolfo Paula</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160614</creationdate><title>Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway</title><author>Alberca-Custódio, Ricardo Wesley ; 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Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma.
Sixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks. Quantification of bronchoalveolar lavage (BAL) cellularity, leukocytes, airway remodeling, interleukin (IL)-5, IL-13, cysteinyl leukotriene (CysLT), and leukotriene B4 (LTB4) in BAL was performed. In addition, quantitative analyses on peribronchial leukocytes and airway epithelium for LT pathway agents: 5-lypoxygenase (5-LO), LTA4 hydrolase (LTA4H), CysLT1 receptor, CysLT2 receptor, LTC4 synthase, and LTB4 receptor 2 (BLT2) were performed. Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography.
AE decreased eosinophils (p < 0.001), neutrophils (p > 0.001), lymphocytes (p < 0.001), and macrophages (p < 0.01) in BAL, as well as eosinophils (p < 0.01), lymphocytes (p < 0.001), and macrophages (p > 0.001) in airway walls. Collagen (p < 0.01), elastic fibers (p < 0.01), mucus production (p < 0.01), and smooth muscle thickness (p < 0.01), as well as IL-5 (p < 0.01), IL-13 (p < 0.01), CysLT (p < 0.01), and LTB4 (p < 0.01) in BAL were reduced. 5-LO (p < 0.05), LTA4H (p < 0.05), CysLT1 receptor (p < 0.001), CysLT2 receptor (p < 0.001), LTC4 synthase (p < 0.001), and BLT2 (p < 0.01) expression by peribronchial leukocytes and airway epithelium were reduced. Lastly, AHR to MCh 25 mg/mL (p < 0.05) and 50 mg/mL (p < 0.01) was reduced.
Moderate-intensity AE attenuated asthma phenotype and LT production in both pulmonary leukocytes and airway epithelium of OVA-treated mice.]]></abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>27379098</pmid><doi>10.3389/fimmu.2016.00237</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Immunology |
| title | Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway |
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