In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development
While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential inf...
Gespeichert in:
| Veröffentlicht in: | Environmental Epigenetics 2016-01, Vol.2 (1), p.dvv013 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | dvv013 |
| container_title | Environmental Epigenetics |
| container_volume | 2 |
| creator | Kappil, Maya A. Li, Qian Li, An Dassanayake, Priyanthi S. Xia, Yulin Nanes, Jessica A. Landrigan, Philip J. Stodgell, Christopher J. Aagaard, Kjersti M. Schadt, Eric E. Dole, Nancy Varner, Michael Moye, John Kasten, Carol Miller, Richard K. Ma, Yula Chen, Jia Lambertini, Luca |
| description | While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential influence of environmental pollutants on the placenta, we assessed the relationship between polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(p- chlorophenyl) ethylene (DDE) and several epigenetic marks linked to fetoplacental development. We measured
IGF2
/
H19
imprint control region methylation,
IGF2
and
H19
expression,
IGF2
loss of imprinting (LOI) and global DNA methylation levels in placenta (
n
= 116) collected in a formative research project of the National Children’s Study to explore the relationship between these epigenetic marks and the selected organic environmental pollutants. A positive association was observed between global DNA methylation and total PBDE levels (
P
|
| doi_str_mv | 10.1093/eep/dvv013 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4905724</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A468772544</galeid><oup_id>10.1093/eep/dvv013</oup_id><sourcerecordid>A468772544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-48c46c4003565d074158ace3df3ea3d78b3ad2d693a836cf9dce3be78169ddf83</originalsourceid><addsrcrecordid>eNp9kU1rHSEYhaU0NCHJpj-gzKZQCjfRcUadTSGEfgQC3SRr8eo7tzaOWnWG9N_XYdKQbooLP855H44chN4SfEHwQC8B4qVZFkzoK3TS4l7seiHE6xfnY3Se80-MMWEtY4K8Qcctp1hg1p-gfOObuUAKDTzGkOcEuSn14hebgp_AF-WakA7KW93E4NxclC-5MTanOZYGoj2Ah1LVSaWH3DjrH8CsjBFKiE7pjWFgARfiSjxDR6NyGc6f9lN0_-Xz3fW33e33rzfXV7c73RFSdp3QHdMdxrRnvcG8I72oNGpGCooaLvZUmdawgSpBmR4HU8U9cEHYYMwo6Cn6tHHjvJ_ArEGScjImW6P-lkFZ-a_i7Q95CIvsBtzztquAD0-AFH7NkIucbNbgnPIQ5iyJaBnHRPC-Wi8260E5kNaPoRJ1XQYmq4OH0db3q44Jztu-W9kftwGdQs4JxudcBMu1WVmblVuz1fzu5U-erX97rIb3myHM8X-gP3DzsNc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826701875</pqid></control><display><type>article</type><title>In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford Journals Open Access Collection</source><source>PubMed Central</source><creator>Kappil, Maya A. ; Li, Qian ; Li, An ; Dassanayake, Priyanthi S. ; Xia, Yulin ; Nanes, Jessica A. ; Landrigan, Philip J. ; Stodgell, Christopher J. ; Aagaard, Kjersti M. ; Schadt, Eric E. ; Dole, Nancy ; Varner, Michael ; Moye, John ; Kasten, Carol ; Miller, Richard K. ; Ma, Yula ; Chen, Jia ; Lambertini, Luca</creator><creatorcontrib>Kappil, Maya A. ; Li, Qian ; Li, An ; Dassanayake, Priyanthi S. ; Xia, Yulin ; Nanes, Jessica A. ; Landrigan, Philip J. ; Stodgell, Christopher J. ; Aagaard, Kjersti M. ; Schadt, Eric E. ; Dole, Nancy ; Varner, Michael ; Moye, John ; Kasten, Carol ; Miller, Richard K. ; Ma, Yula ; Chen, Jia ; Lambertini, Luca</creatorcontrib><description>While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential influence of environmental pollutants on the placenta, we assessed the relationship between polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(p- chlorophenyl) ethylene (DDE) and several epigenetic marks linked to fetoplacental development. We measured
IGF2
/
H19
imprint control region methylation,
IGF2
and
H19
expression,
IGF2
loss of imprinting (LOI) and global DNA methylation levels in placenta (
n
= 116) collected in a formative research project of the National Children’s Study to explore the relationship between these epigenetic marks and the selected organic environmental pollutants. A positive association was observed between global DNA methylation and total PBDE levels (
P
< 0.01) and between
H19
expression and total PCB levels (
P
= 0.04). These findings suggest that differences in specific epigenetic marks linked to fetoplacental development occur in association with some, but not all, measured environmental exposures.</description><identifier>ISSN: 2058-5888</identifier><identifier>EISSN: 2058-5888</identifier><identifier>DOI: 10.1093/eep/dvv013</identifier><identifier>PMID: 27308065</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Environmental aspects ; Epigenetic inheritance ; Fetus ; Genetic aspects ; Growth ; Health aspects ; Pollutants</subject><ispartof>Environmental Epigenetics, 2016-01, Vol.2 (1), p.dvv013</ispartof><rights>The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2016</rights><rights>COPYRIGHT 2016 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-48c46c4003565d074158ace3df3ea3d78b3ad2d693a836cf9dce3be78169ddf83</citedby><cites>FETCH-LOGICAL-c411t-48c46c4003565d074158ace3df3ea3d78b3ad2d693a836cf9dce3be78169ddf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905724/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905724/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,1601,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27308065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kappil, Maya A.</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Li, An</creatorcontrib><creatorcontrib>Dassanayake, Priyanthi S.</creatorcontrib><creatorcontrib>Xia, Yulin</creatorcontrib><creatorcontrib>Nanes, Jessica A.</creatorcontrib><creatorcontrib>Landrigan, Philip J.</creatorcontrib><creatorcontrib>Stodgell, Christopher J.</creatorcontrib><creatorcontrib>Aagaard, Kjersti M.</creatorcontrib><creatorcontrib>Schadt, Eric E.</creatorcontrib><creatorcontrib>Dole, Nancy</creatorcontrib><creatorcontrib>Varner, Michael</creatorcontrib><creatorcontrib>Moye, John</creatorcontrib><creatorcontrib>Kasten, Carol</creatorcontrib><creatorcontrib>Miller, Richard K.</creatorcontrib><creatorcontrib>Ma, Yula</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Lambertini, Luca</creatorcontrib><title>In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development</title><title>Environmental Epigenetics</title><addtitle>Environ Epigenet</addtitle><description>While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential influence of environmental pollutants on the placenta, we assessed the relationship between polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(p- chlorophenyl) ethylene (DDE) and several epigenetic marks linked to fetoplacental development. We measured
IGF2
/
H19
imprint control region methylation,
IGF2
and
H19
expression,
IGF2
loss of imprinting (LOI) and global DNA methylation levels in placenta (
n
= 116) collected in a formative research project of the National Children’s Study to explore the relationship between these epigenetic marks and the selected organic environmental pollutants. A positive association was observed between global DNA methylation and total PBDE levels (
P
< 0.01) and between
H19
expression and total PCB levels (
P
= 0.04). These findings suggest that differences in specific epigenetic marks linked to fetoplacental development occur in association with some, but not all, measured environmental exposures.</description><subject>Environmental aspects</subject><subject>Epigenetic inheritance</subject><subject>Fetus</subject><subject>Genetic aspects</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Pollutants</subject><issn>2058-5888</issn><issn>2058-5888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU1rHSEYhaU0NCHJpj-gzKZQCjfRcUadTSGEfgQC3SRr8eo7tzaOWnWG9N_XYdKQbooLP855H44chN4SfEHwQC8B4qVZFkzoK3TS4l7seiHE6xfnY3Se80-MMWEtY4K8Qcctp1hg1p-gfOObuUAKDTzGkOcEuSn14hebgp_AF-WakA7KW93E4NxclC-5MTanOZYGoj2Ah1LVSaWH3DjrH8CsjBFKiE7pjWFgARfiSjxDR6NyGc6f9lN0_-Xz3fW33e33rzfXV7c73RFSdp3QHdMdxrRnvcG8I72oNGpGCooaLvZUmdawgSpBmR4HU8U9cEHYYMwo6Cn6tHHjvJ_ArEGScjImW6P-lkFZ-a_i7Q95CIvsBtzztquAD0-AFH7NkIucbNbgnPIQ5iyJaBnHRPC-Wi8260E5kNaPoRJ1XQYmq4OH0db3q44Jztu-W9kftwGdQs4JxudcBMu1WVmblVuz1fzu5U-erX97rIb3myHM8X-gP3DzsNc</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kappil, Maya A.</creator><creator>Li, Qian</creator><creator>Li, An</creator><creator>Dassanayake, Priyanthi S.</creator><creator>Xia, Yulin</creator><creator>Nanes, Jessica A.</creator><creator>Landrigan, Philip J.</creator><creator>Stodgell, Christopher J.</creator><creator>Aagaard, Kjersti M.</creator><creator>Schadt, Eric E.</creator><creator>Dole, Nancy</creator><creator>Varner, Michael</creator><creator>Moye, John</creator><creator>Kasten, Carol</creator><creator>Miller, Richard K.</creator><creator>Ma, Yula</creator><creator>Chen, Jia</creator><creator>Lambertini, Luca</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development</title><author>Kappil, Maya A. ; Li, Qian ; Li, An ; Dassanayake, Priyanthi S. ; Xia, Yulin ; Nanes, Jessica A. ; Landrigan, Philip J. ; Stodgell, Christopher J. ; Aagaard, Kjersti M. ; Schadt, Eric E. ; Dole, Nancy ; Varner, Michael ; Moye, John ; Kasten, Carol ; Miller, Richard K. ; Ma, Yula ; Chen, Jia ; Lambertini, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-48c46c4003565d074158ace3df3ea3d78b3ad2d693a836cf9dce3be78169ddf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Environmental aspects</topic><topic>Epigenetic inheritance</topic><topic>Fetus</topic><topic>Genetic aspects</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Pollutants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kappil, Maya A.</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Li, An</creatorcontrib><creatorcontrib>Dassanayake, Priyanthi S.</creatorcontrib><creatorcontrib>Xia, Yulin</creatorcontrib><creatorcontrib>Nanes, Jessica A.</creatorcontrib><creatorcontrib>Landrigan, Philip J.</creatorcontrib><creatorcontrib>Stodgell, Christopher J.</creatorcontrib><creatorcontrib>Aagaard, Kjersti M.</creatorcontrib><creatorcontrib>Schadt, Eric E.</creatorcontrib><creatorcontrib>Dole, Nancy</creatorcontrib><creatorcontrib>Varner, Michael</creatorcontrib><creatorcontrib>Moye, John</creatorcontrib><creatorcontrib>Kasten, Carol</creatorcontrib><creatorcontrib>Miller, Richard K.</creatorcontrib><creatorcontrib>Ma, Yula</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Lambertini, Luca</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental Epigenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kappil, Maya A.</au><au>Li, Qian</au><au>Li, An</au><au>Dassanayake, Priyanthi S.</au><au>Xia, Yulin</au><au>Nanes, Jessica A.</au><au>Landrigan, Philip J.</au><au>Stodgell, Christopher J.</au><au>Aagaard, Kjersti M.</au><au>Schadt, Eric E.</au><au>Dole, Nancy</au><au>Varner, Michael</au><au>Moye, John</au><au>Kasten, Carol</au><au>Miller, Richard K.</au><au>Ma, Yula</au><au>Chen, Jia</au><au>Lambertini, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development</atitle><jtitle>Environmental Epigenetics</jtitle><addtitle>Environ Epigenet</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2</volume><issue>1</issue><spage>dvv013</spage><pages>dvv013-</pages><issn>2058-5888</issn><eissn>2058-5888</eissn><abstract>While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential influence of environmental pollutants on the placenta, we assessed the relationship between polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(p- chlorophenyl) ethylene (DDE) and several epigenetic marks linked to fetoplacental development. We measured
IGF2
/
H19
imprint control region methylation,
IGF2
and
H19
expression,
IGF2
loss of imprinting (LOI) and global DNA methylation levels in placenta (
n
= 116) collected in a formative research project of the National Children’s Study to explore the relationship between these epigenetic marks and the selected organic environmental pollutants. A positive association was observed between global DNA methylation and total PBDE levels (
P
< 0.01) and between
H19
expression and total PCB levels (
P
= 0.04). These findings suggest that differences in specific epigenetic marks linked to fetoplacental development occur in association with some, but not all, measured environmental exposures.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>27308065</pmid><doi>10.1093/eep/dvv013</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2058-5888 |
| ispartof | Environmental Epigenetics, 2016-01, Vol.2 (1), p.dvv013 |
| issn | 2058-5888 2058-5888 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4905724 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Environmental aspects Epigenetic inheritance Fetus Genetic aspects Growth Health aspects Pollutants |
| title | In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A33%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20utero%20exposures%20to%20environmental%20organic%20pollutants%20disrupt%20epigenetic%20marks%20linked%20to%20fetoplacental%20development&rft.jtitle=Environmental%20Epigenetics&rft.au=Kappil,%20Maya%20A.&rft.date=2016-01-01&rft.volume=2&rft.issue=1&rft.spage=dvv013&rft.pages=dvv013-&rft.issn=2058-5888&rft.eissn=2058-5888&rft_id=info:doi/10.1093/eep/dvv013&rft_dat=%3Cgale_pubme%3EA468772544%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1826701875&rft_id=info:pmid/27308065&rft_galeid=A468772544&rft_oup_id=10.1093/eep/dvv013&rfr_iscdi=true |