First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

IL-4 and IL-13 are closely related canonical type-2 cytokines in mammals and have overlapping bioactivities via shared receptors. They are frequently activated together as part of the same immune response and are the signature cytokines produced by T-helper (Th)2 cells and type-2 innate lymphoid cel...

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Veröffentlicht in:	Oncotarget 2016-03, Vol.7 (10), p.10917-10946
Hauptverfasser:	Wang, Tiehui, Johansson, Petronella, Abós, Beatriz, Holt, Amy, Tafalla, Carolina, Jiang, Youshen, Wang, Alex, Xu, Qiaoqing, Qi, Zhitao, Huang, Wenshu, Costa, Maria M, Diaz-Rosales, Patricia, Holland, Jason W, Secombes, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - biosynthesis Cytokines - immunology Gene Expression Interleukin-13 - immunology Interleukin-4 - immunology Oncorhynchus mykiss - genetics Oncorhynchus mykiss - immunology Research Paper: Immunology Th2 Cells - immunology
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