HIV-1 Vpu Mediates HLA-C Downregulation

Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -B but not HLA-C molecules....

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Veröffentlicht in:	Cell host & microbe 2016-05, Vol.19 (5), p.686-695
Hauptverfasser:	Apps, Richard, Del Prete, Gregory Q., Chatterjee, Pramita, Lara, Abigail, Brumme, Zabrina L., Brockman, Mark A., Neil, Stuart, Pickering, Suzanne, Schneider, Douglas K., Piechocka-Trocha, Alicja, Walker, Bruce D., Thomas, Rasmi, Shaw, George M., Hahn, Beatrice H., Keele, Brandon F., Lifson, Jeffrey D., Carrington, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cloning, Molecular Cytotoxicity, Immunologic Down-Regulation HeLa Cells HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV-1 - genetics HIV-1 - immunology HIV-1 - metabolism HLA-C Antigens - immunology HLA-C Antigens - metabolism Human Immunodeficiency Virus Proteins - genetics Human Immunodeficiency Virus Proteins - immunology Human Immunodeficiency Virus Proteins - metabolism Humans Immune Evasion Killer Cells, Natural - immunology Mutation T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - virology Transfection Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - immunology Viral Regulatory and Accessory Proteins - metabolism Virus Replication
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