Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

Objective The authors tested whether the anti-interleukin (IL)-17A monoclonal antibody secukinumab was safe and effective for the treatment of active Crohn's disease. Design In a double-blind, randomised, placebo-controlled proof-of-concept study, 59 patients with moderate to severe Crohn'...

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Veröffentlicht in:	Gut 2012-12, Vol.61 (12), p.1693-1700
Hauptverfasser:	Hueber, Wolfgang, Sands, Bruce E, Lewitzky, Steve, Vandemeulebroecke, Marc, Reinisch, Walter, Higgins, Peter D R, Wehkamp, Jan, Feagan, Brian G, Yao, Michael D, Karczewski, Marek, Karczewski, Jacek, Pezous, Nicole, Bek, Stephan, Bruin, Gerard, Mellgard, Bjoern, Berger, Claudia, Londei, Marco, Bertolino, Arthur P, Tougas, Gervais, Travis, Simon P L
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminosalicylic acid Adolescent Adult Aged Anti-Inflammatory Agents - therapeutic use antibacterial mucosal immunity antibacterial peptide Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized antibody targeted therapy Bayes Theorem Biological and medical sciences Biomarkers - metabolism Biomedical research chronic IBD clinical trials Crohn Disease - drug therapy Crohn Disease - genetics Crohn's disease Cytokines Double-Blind Method Drug Administration Schedule Female Gangrene Gastroenterology. Liver. Pancreas. Abdomen Genetic Markers genetic polymorphisms genetics Genomes genotype gut immunology gut inflammation Humans Hypotheses Hypothesis testing IBD basic research immune response immunology immunoregulation Inflammation Inflammatory bowel disease inflammatory mediators infliximab Infusions, Intravenous Interleukin-17 - antagonists & inhibitors Interleukin-17 - genetics Leukocyte L1 Antigen Complex - metabolism Male Medical sciences Middle Aged mucosal defense Other diseases. Semiology Pathogenesis Patients Pharmaceutical industry pharmacogenetics pharmacokinetics pharmacology Polymorphism, Single Nucleotide Prescription drugs Psoriasis Severity of Illness Index statistics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies Treatment Failure ulcerative colitis Young Adult
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