Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans

Emerging evidence supports an important role for T cells in the genesis of hypertension. Because this work has predominantly been performed in experimental animals, we sought to determine whether human T cells are activated in hypertension. We used a humanized mouse model in which the murine immune...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-07, Vol.68 (1), p.123-132
Hauptverfasser:	Itani, Hana A, McMaster, William G, Saleh, Mohamed A, Nazarewicz, Rafal R, Mikolajczyk, Tomasz P, Kaszuba, Anna M, Konior, Anna, Prejbisz, Aleksander, Januszewicz, Andrzej, Norlander, Allison E, Chen, Wei, Bonami, Rachel H, Marshall, Andrew F, Poffenberger, Greg, Weyand, Cornelia M, Madhur, Meena S, Moore, Daniel J, Harrison, David G, Guzik, Tomasz J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Angiotensin II - pharmacology Animals Antibodies, Monoclonal, Humanized - immunology Cells, Cultured - drug effects Cells, Cultured - immunology Chi-Square Distribution Disease Models, Animal Humans Hypertension - drug therapy Hypertension - immunology Hypertension - physiopathology Kidney - drug effects Kidney - immunology Kidney - metabolism Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mice Middle Aged Random Allocation Reference Values Sampling Studies Statistics, Nonparametric T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology
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