Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability, and tissue heterogeneity limit their broad applications. Here, we developed a miniaturized spinning bioreactor (SpinΩ) to generate forebrain...

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Veröffentlicht in:	Cell 2016-05, Vol.165 (5), p.1238-1254
Hauptverfasser:	Qian, Xuyu, Nguyen, Ha Nam, Song, Mingxi M., Hadiono, Christopher, Ogden, Sarah C., Hammack, Christy, Yao, Bing, Hamersky, Gregory R., Jacob, Fadi, Zhong, Chun, Yoon, Ki-jun, Jeang, William, Lin, Li, Li, Yujing, Thakor, Jai, Berg, Daniel A., Zhang, Ce, Kang, Eunchai, Chickering, Michael, Nauen, David, Ho, Cheng-Ying, Wen, Zhexing, Christian, Kimberly M., Shi, Pei-Yong, Maher, Brady J., Wu, Hao, Jin, Peng, Tang, Hengli, Song, Hongjun, Ming, Guo-li
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral agents Bioreactors brain Brain - cytology Cell Culture Techniques - economics cell death Embryo, Mammalian Embryonic Development gene expression Humans Induced Pluripotent Stem Cells Models, Biological Neurogenesis neurons Neurons - cytology Organoids - virology quantitative analysis spinning Zika virus Zika Virus - physiology Zika Virus Infection - physiopathology Zika Virus Infection - virology
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