Nitrone Cycloadditions of 1,2-Cyclohexadiene

We report the first 1,3-dipolar cycloadditions of 1,2-cyclohexadiene, a rarely exploited strained allene. 1,2-Cyclohexadiene is generated in situ under mild conditions and trapped with nitrones to give isoxazolidine products in synthetically useful yields. The reactions occur regioselectively and ex...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2016-03, Vol.138 (8), p.2512-2515
Hauptverfasser:	Barber, Joyann S, Styduhar, Evan D, Pham, Hung V, McMahon, Travis C, Houk, K. N, Garg, Neil K
Format:	Artikel
Sprache:	eng
Schlagworte:	allene Allyl Compounds - chemistry Cycloaddition Reaction cycloaddition reactions Cyclohexenes - chemistry Heterocyclic Compounds - chemical synthesis Nitrogen Oxides - chemistry Stereoisomerism synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!