Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial
Obesity and depression are two prevalent conditions that are costly to individuals and society. The bidirectional association of obesity with depression, in which unhealthy dietary patterns may play an important role, has been well established. Few experimental studies have been conducted to investi...
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creator | Roca, Miquel Kohls, Elisabeth Gili, Margalida Watkins, Ed Owens, Matthew Hegerl, Ulrich van Grootheest, Gerard Bot, Mariska Cabout, Mieke Brouwer, Ingeborg A Visser, Marjolein Penninx, Brenda W |
description | Obesity and depression are two prevalent conditions that are costly to individuals and society. The bidirectional association of obesity with depression, in which unhealthy dietary patterns may play an important role, has been well established. Few experimental studies have been conducted to investigate whether supplementing specific nutrients or improving diet and food-related behaviors can prevent depression in overweight persons.
The MooDFOOD prevention trial examines the feasibility and effectiveness of two different nutritional strategies [multi-nutrient supplementation and food-related behavioral change therapy (FBC)] to prevent depression in individuals who are overweight and have elevated depressive symptoms but who are not currently or in the last 6 months meeting criteria for an episode of major depressive disorder (MDD). The randomized controlled prevention trial has a two-by-two factorial design: participants are randomized to daily multi-nutrient supplement (omega-3 fatty acids, calcium, selenium, B-11 vitamin and D-3 vitamin) versus placebo, and/or FBC therapy sessions versus usual care. Interventions last 12 months. In total 1000 participants aged 18-75 years with body mass index between 25-40 kg/m(2) and with a Patient Health Questionnaire-9 score ≥ 5 will be recruited at four study sites in four European countries. Baseline and follow-up assessments take place at 0, 3, 6, and 12 months. Primary endpoint is the onset of an episode of MDD, assessed according to DSM-IV based criteria using the MINI 5.0 interview. Depressive symptoms, anxiety, food and eating behavior, physical activity and health related quality of life are secondary outcomes. During the intervention, compliance, adverse events and potentially mediating variables are carefully monitored.
The trial aims to provide a better understanding of the causal role of specific nutrients, overall diet, and food-related behavior change with respect to the incidence of MDD episodes. This knowledge will be used to develop and disseminate innovative evidence-based, feasible, and effective nutritional public health strategies for the prevention of clinical depression.
ClinicalTrials.gov. Number of identification: NCT02529423 . August 2015. |
doi_str_mv | 10.1186/s12888-016-0900-z |
format | Article |
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The MooDFOOD prevention trial examines the feasibility and effectiveness of two different nutritional strategies [multi-nutrient supplementation and food-related behavioral change therapy (FBC)] to prevent depression in individuals who are overweight and have elevated depressive symptoms but who are not currently or in the last 6 months meeting criteria for an episode of major depressive disorder (MDD). The randomized controlled prevention trial has a two-by-two factorial design: participants are randomized to daily multi-nutrient supplement (omega-3 fatty acids, calcium, selenium, B-11 vitamin and D-3 vitamin) versus placebo, and/or FBC therapy sessions versus usual care. Interventions last 12 months. In total 1000 participants aged 18-75 years with body mass index between 25-40 kg/m(2) and with a Patient Health Questionnaire-9 score ≥ 5 will be recruited at four study sites in four European countries. Baseline and follow-up assessments take place at 0, 3, 6, and 12 months. Primary endpoint is the onset of an episode of MDD, assessed according to DSM-IV based criteria using the MINI 5.0 interview. Depressive symptoms, anxiety, food and eating behavior, physical activity and health related quality of life are secondary outcomes. During the intervention, compliance, adverse events and potentially mediating variables are carefully monitored.
The trial aims to provide a better understanding of the causal role of specific nutrients, overall diet, and food-related behavior change with respect to the incidence of MDD episodes. This knowledge will be used to develop and disseminate innovative evidence-based, feasible, and effective nutritional public health strategies for the prevention of clinical depression.
ClinicalTrials.gov. Number of identification: NCT02529423 . August 2015.</description><identifier>ISSN: 1471-244X</identifier><identifier>EISSN: 1471-244X</identifier><identifier>DOI: 10.1186/s12888-016-0900-z</identifier><identifier>PMID: 27277946</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anxiety ; Behavior Therapy - methods ; Clinical Protocols ; Complications and side effects ; Depression - prevention & control ; Depression, Mental ; Depressive Disorder, Major - prevention & control ; Diet ; Diet - methods ; Diet - psychology ; Diet therapy ; Diet Therapy - methods ; Diet Therapy - psychology ; Dietary Supplements ; Eating behavior ; Europe ; Fatty acids ; Feasibility Studies ; Feeding Behavior - psychology ; Female ; Food ; Food and nutrition ; Food habits ; Health aspects ; Health care ; Humans ; Intervention ; Male ; Mental depression ; Middle Aged ; Nutrition research ; Obesity ; Obesity - diet therapy ; Obesity - psychology ; Overweight ; Overweight - diet therapy ; Overweight - psychology ; Overweight persons ; Prevention ; Psychiatry ; Psychological aspects ; Quality of Life ; Research Design ; Risk Factors ; Selenium ; Study Protocol ; Vitamins ; Young Adult</subject><ispartof>BMC psychiatry, 2016-06, Vol.16 (1), p.192-192, Article 192</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-2aa3bfaaf696eb6fc5e40e4fbdfadf44b9c84d214e045e400b65e58ddff2adb73</citedby><cites>FETCH-LOGICAL-c560t-2aa3bfaaf696eb6fc5e40e4fbdfadf44b9c84d214e045e400b65e58ddff2adb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898322/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898322/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27277946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roca, Miquel</creatorcontrib><creatorcontrib>Kohls, Elisabeth</creatorcontrib><creatorcontrib>Gili, Margalida</creatorcontrib><creatorcontrib>Watkins, Ed</creatorcontrib><creatorcontrib>Owens, Matthew</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>van Grootheest, Gerard</creatorcontrib><creatorcontrib>Bot, Mariska</creatorcontrib><creatorcontrib>Cabout, Mieke</creatorcontrib><creatorcontrib>Brouwer, Ingeborg A</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Penninx, Brenda W</creatorcontrib><creatorcontrib>MooDFOOD Prevention Trial Investigators</creatorcontrib><creatorcontrib>on behalf of the MooDFOOD Prevention Trial Investigators</creatorcontrib><title>Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial</title><title>BMC psychiatry</title><addtitle>BMC Psychiatry</addtitle><description>Obesity and depression are two prevalent conditions that are costly to individuals and society. The bidirectional association of obesity with depression, in which unhealthy dietary patterns may play an important role, has been well established. Few experimental studies have been conducted to investigate whether supplementing specific nutrients or improving diet and food-related behaviors can prevent depression in overweight persons.
The MooDFOOD prevention trial examines the feasibility and effectiveness of two different nutritional strategies [multi-nutrient supplementation and food-related behavioral change therapy (FBC)] to prevent depression in individuals who are overweight and have elevated depressive symptoms but who are not currently or in the last 6 months meeting criteria for an episode of major depressive disorder (MDD). The randomized controlled prevention trial has a two-by-two factorial design: participants are randomized to daily multi-nutrient supplement (omega-3 fatty acids, calcium, selenium, B-11 vitamin and D-3 vitamin) versus placebo, and/or FBC therapy sessions versus usual care. Interventions last 12 months. In total 1000 participants aged 18-75 years with body mass index between 25-40 kg/m(2) and with a Patient Health Questionnaire-9 score ≥ 5 will be recruited at four study sites in four European countries. Baseline and follow-up assessments take place at 0, 3, 6, and 12 months. Primary endpoint is the onset of an episode of MDD, assessed according to DSM-IV based criteria using the MINI 5.0 interview. Depressive symptoms, anxiety, food and eating behavior, physical activity and health related quality of life are secondary outcomes. During the intervention, compliance, adverse events and potentially mediating variables are carefully monitored.
The trial aims to provide a better understanding of the causal role of specific nutrients, overall diet, and food-related behavior change with respect to the incidence of MDD episodes. This knowledge will be used to develop and disseminate innovative evidence-based, feasible, and effective nutritional public health strategies for the prevention of clinical depression.
ClinicalTrials.gov. Number of identification: NCT02529423 . August 2015.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Behavior Therapy - methods</subject><subject>Clinical Protocols</subject><subject>Complications and side effects</subject><subject>Depression - prevention & control</subject><subject>Depression, Mental</subject><subject>Depressive Disorder, Major - prevention & control</subject><subject>Diet</subject><subject>Diet - methods</subject><subject>Diet - psychology</subject><subject>Diet therapy</subject><subject>Diet Therapy - methods</subject><subject>Diet Therapy - psychology</subject><subject>Dietary Supplements</subject><subject>Eating behavior</subject><subject>Europe</subject><subject>Fatty acids</subject><subject>Feasibility Studies</subject><subject>Feeding Behavior - psychology</subject><subject>Female</subject><subject>Food</subject><subject>Food and nutrition</subject><subject>Food habits</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Humans</subject><subject>Intervention</subject><subject>Male</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - diet therapy</subject><subject>Obesity - psychology</subject><subject>Overweight</subject><subject>Overweight - diet therapy</subject><subject>Overweight - psychology</subject><subject>Overweight persons</subject><subject>Prevention</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Quality of Life</subject><subject>Research Design</subject><subject>Risk Factors</subject><subject>Selenium</subject><subject>Study Protocol</subject><subject>Vitamins</subject><subject>Young Adult</subject><issn>1471-244X</issn><issn>1471-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUktvFSEUJkZja_UHuDEkbtxMhbkMMC5MmtaqSZvrok3cEWY4zFDnwhRmmtitf1ymt_ZhGkJ4fI8DJx9CbynZp1Tyj4mWUsqCUF6QmpDi-hnapUzQomTs5_MH-x30KqULQqiQFX2JdkpRClEzvov-_IhwBX5yweNgsYExQkrLaepjmLse-3mKbsH1gNMU9QSdg4Sdx73r-iK69AuPEFPw6RPO8A0TsPYmuyXX3fhOPeDTEI6O1-sjPN6XzNZ6eI1eWD0keHO77qHz4y9nh9-Kk_XX74cHJ0VbcTIVpdarxmptec2h4batgBFgtjFWG8tYU7eSmZIyIGyBSMMrqKQx1pbaNGK1hz5vfce52YBp8xuiHtQY3UbH3ypopx4j3vWqC1eKyVquyjIbfLg1iOFyhjSpjUstDIP2EOakqKgryQljVaa-_496EeaYO5NZkhBBZcXlPavLLVPO25DrtoupOmBcSpEnz6z9J1h5GNi4NniwLt8_EtCtoI0hpQj27o-UqCU5apsclZOjluSo66x597A5d4p_UVn9BcF-wv8</recordid><startdate>20160608</startdate><enddate>20160608</enddate><creator>Roca, Miquel</creator><creator>Kohls, Elisabeth</creator><creator>Gili, Margalida</creator><creator>Watkins, Ed</creator><creator>Owens, Matthew</creator><creator>Hegerl, Ulrich</creator><creator>van Grootheest, Gerard</creator><creator>Bot, Mariska</creator><creator>Cabout, Mieke</creator><creator>Brouwer, Ingeborg A</creator><creator>Visser, Marjolein</creator><creator>Penninx, Brenda W</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160608</creationdate><title>Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial</title><author>Roca, Miquel ; Kohls, Elisabeth ; Gili, Margalida ; Watkins, Ed ; Owens, Matthew ; Hegerl, Ulrich ; van Grootheest, Gerard ; Bot, Mariska ; Cabout, Mieke ; Brouwer, Ingeborg A ; Visser, Marjolein ; Penninx, Brenda W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-2aa3bfaaf696eb6fc5e40e4fbdfadf44b9c84d214e045e400b65e58ddff2adb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Behavior Therapy - methods</topic><topic>Clinical Protocols</topic><topic>Complications and side effects</topic><topic>Depression - prevention & control</topic><topic>Depression, Mental</topic><topic>Depressive Disorder, Major - prevention & control</topic><topic>Diet</topic><topic>Diet - methods</topic><topic>Diet - psychology</topic><topic>Diet therapy</topic><topic>Diet Therapy - methods</topic><topic>Diet Therapy - psychology</topic><topic>Dietary Supplements</topic><topic>Eating behavior</topic><topic>Europe</topic><topic>Fatty acids</topic><topic>Feasibility Studies</topic><topic>Feeding Behavior - psychology</topic><topic>Female</topic><topic>Food</topic><topic>Food and nutrition</topic><topic>Food habits</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Humans</topic><topic>Intervention</topic><topic>Male</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - diet therapy</topic><topic>Obesity - psychology</topic><topic>Overweight</topic><topic>Overweight - diet therapy</topic><topic>Overweight - psychology</topic><topic>Overweight persons</topic><topic>Prevention</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Quality of Life</topic><topic>Research Design</topic><topic>Risk Factors</topic><topic>Selenium</topic><topic>Study Protocol</topic><topic>Vitamins</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roca, Miquel</creatorcontrib><creatorcontrib>Kohls, Elisabeth</creatorcontrib><creatorcontrib>Gili, Margalida</creatorcontrib><creatorcontrib>Watkins, Ed</creatorcontrib><creatorcontrib>Owens, Matthew</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>van Grootheest, Gerard</creatorcontrib><creatorcontrib>Bot, Mariska</creatorcontrib><creatorcontrib>Cabout, Mieke</creatorcontrib><creatorcontrib>Brouwer, Ingeborg A</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Penninx, Brenda W</creatorcontrib><creatorcontrib>MooDFOOD Prevention Trial Investigators</creatorcontrib><creatorcontrib>on behalf of the MooDFOOD Prevention Trial Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roca, Miquel</au><au>Kohls, Elisabeth</au><au>Gili, Margalida</au><au>Watkins, Ed</au><au>Owens, Matthew</au><au>Hegerl, Ulrich</au><au>van Grootheest, Gerard</au><au>Bot, Mariska</au><au>Cabout, Mieke</au><au>Brouwer, Ingeborg A</au><au>Visser, Marjolein</au><au>Penninx, Brenda W</au><aucorp>MooDFOOD Prevention Trial Investigators</aucorp><aucorp>on behalf of the MooDFOOD Prevention Trial Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial</atitle><jtitle>BMC psychiatry</jtitle><addtitle>BMC Psychiatry</addtitle><date>2016-06-08</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>192</spage><epage>192</epage><pages>192-192</pages><artnum>192</artnum><issn>1471-244X</issn><eissn>1471-244X</eissn><abstract>Obesity and depression are two prevalent conditions that are costly to individuals and society. The bidirectional association of obesity with depression, in which unhealthy dietary patterns may play an important role, has been well established. Few experimental studies have been conducted to investigate whether supplementing specific nutrients or improving diet and food-related behaviors can prevent depression in overweight persons.
The MooDFOOD prevention trial examines the feasibility and effectiveness of two different nutritional strategies [multi-nutrient supplementation and food-related behavioral change therapy (FBC)] to prevent depression in individuals who are overweight and have elevated depressive symptoms but who are not currently or in the last 6 months meeting criteria for an episode of major depressive disorder (MDD). The randomized controlled prevention trial has a two-by-two factorial design: participants are randomized to daily multi-nutrient supplement (omega-3 fatty acids, calcium, selenium, B-11 vitamin and D-3 vitamin) versus placebo, and/or FBC therapy sessions versus usual care. Interventions last 12 months. In total 1000 participants aged 18-75 years with body mass index between 25-40 kg/m(2) and with a Patient Health Questionnaire-9 score ≥ 5 will be recruited at four study sites in four European countries. Baseline and follow-up assessments take place at 0, 3, 6, and 12 months. Primary endpoint is the onset of an episode of MDD, assessed according to DSM-IV based criteria using the MINI 5.0 interview. Depressive symptoms, anxiety, food and eating behavior, physical activity and health related quality of life are secondary outcomes. During the intervention, compliance, adverse events and potentially mediating variables are carefully monitored.
The trial aims to provide a better understanding of the causal role of specific nutrients, overall diet, and food-related behavior change with respect to the incidence of MDD episodes. This knowledge will be used to develop and disseminate innovative evidence-based, feasible, and effective nutritional public health strategies for the prevention of clinical depression.
ClinicalTrials.gov. Number of identification: NCT02529423 . August 2015.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27277946</pmid><doi>10.1186/s12888-016-0900-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Anxiety Behavior Therapy - methods Clinical Protocols Complications and side effects Depression - prevention & control Depression, Mental Depressive Disorder, Major - prevention & control Diet Diet - methods Diet - psychology Diet therapy Diet Therapy - methods Diet Therapy - psychology Dietary Supplements Eating behavior Europe Fatty acids Feasibility Studies Feeding Behavior - psychology Female Food Food and nutrition Food habits Health aspects Health care Humans Intervention Male Mental depression Middle Aged Nutrition research Obesity Obesity - diet therapy Obesity - psychology Overweight Overweight - diet therapy Overweight - psychology Overweight persons Prevention Psychiatry Psychological aspects Quality of Life Research Design Risk Factors Selenium Study Protocol Vitamins Young Adult |
title | Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial |
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