Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas

Malignant gliomas are highly lethal tumors resistant to current therapies. The standard treatment modality for these tumors, surgical resection followed by radiation therapy and concurrent temozolomide, has demonstrated activity, but development of resistance and disease progression is common. Altho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuro-oncology 2011-08, Vol.104 (1), p.179-189
Hauptverfasser:	Chaponis, Deviney, Barnes, Jessica W., Dellagatta, Jamie L., Kesari, Santosh, Fast, Eva, Sauvageot, Claire, Panagrahy, Dipak, Greene, Emily R., Ramakrishna, Naren, Wen, Patrick Y., Kung, Andrew L., Stiles, Charles, Kieran, Mark W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - therapeutic use Brain Neoplasms - therapy Cell Line, Tumor Cell Proliferation - drug effects Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Drug Synergism Glioma - therapy Humans Laboratory Investigation - Human/Animal Tissue Medicine Medicine & Public Health Mice Neoplasm Transplantation Neurology Oncology Piperidines - therapeutic use Prenylation - drug effects Pyridines - therapeutic use Radiation, Ionizing ras Proteins - metabolism Signal Transduction - drug effects Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!