Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

Recent studies have highlighted the fact that cancer cells have an altered metabolic phenotype, and this metabolic reprogramming is required to drive the biosynthesis pathways necessary for rapid replication and proliferation. Specifically, the importance of citric acid cycle-generated intermediates...

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Veröffentlicht in:	Biochemical journal 2012-06, Vol.444 (3), p.561-571
Hauptverfasser:	Diers, Anne R, Broniowska, Katarzyna A, Chang, Ching-Fang, Hogg, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Respiration - drug effects Cell Respiration - physiology Coumaric Acids - pharmacology Female Humans Mitochondria - drug effects Mitochondria - metabolism Monocarboxylic Acid Transporters - antagonists & inhibitors Monocarboxylic Acid Transporters - metabolism Pyruvic Acid - antagonists & inhibitors Pyruvic Acid - metabolism Pyruvic Acid - pharmacology
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