Interleukin-6: an emerging regulator of pathological pain
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and...
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| Veröffentlicht in: | Journal of neuroinflammation 2016-06, Vol.13 (1), p.141-141, Article 141 |
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| container_title | Journal of neuroinflammation |
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| creator | Zhou, Ya-Qun Liu, Zheng Liu, Zhi-Heng Chen, Shu-Ping Li, Man Shahveranov, Allahverdi Ye, Da-Wei Tian, Yu-Ke |
| description | Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain. |
| doi_str_mv | 10.1186/s12974-016-0607-6 |
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It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.</description><identifier>ISSN: 1742-2094</identifier><identifier>EISSN: 1742-2094</identifier><identifier>DOI: 10.1186/s12974-016-0607-6</identifier><identifier>PMID: 27267059</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Chemotherapy ; Health aspects ; Humans ; Interleukin-6 ; Interleukin-6 - physiology ; Interleukin-6 - toxicity ; Pain ; Pain - chemically induced ; Pain - metabolism ; Pain - pathology ; Pain Measurement - drug effects ; Pain Measurement - methods ; Review ; Risk factors ; Signal Transduction - drug effects ; Signal Transduction - physiology</subject><ispartof>Journal of neuroinflammation, 2016-06, Vol.13 (1), p.141-141, Article 141</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-f30264a3c490618265da17873f089543ff6754e84703415003f4852d107cadf03</citedby><cites>FETCH-LOGICAL-c542t-f30264a3c490618265da17873f089543ff6754e84703415003f4852d107cadf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897919/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897919/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27267059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Ya-Qun</creatorcontrib><creatorcontrib>Liu, Zheng</creatorcontrib><creatorcontrib>Liu, Zhi-Heng</creatorcontrib><creatorcontrib>Chen, Shu-Ping</creatorcontrib><creatorcontrib>Li, Man</creatorcontrib><creatorcontrib>Shahveranov, Allahverdi</creatorcontrib><creatorcontrib>Ye, Da-Wei</creatorcontrib><creatorcontrib>Tian, Yu-Ke</creatorcontrib><title>Interleukin-6: an emerging regulator of pathological pain</title><title>Journal of neuroinflammation</title><addtitle>J Neuroinflammation</addtitle><description>Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.</description><subject>Animals</subject><subject>Chemotherapy</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - physiology</subject><subject>Interleukin-6 - toxicity</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - metabolism</subject><subject>Pain - pathology</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Measurement - methods</subject><subject>Review</subject><subject>Risk factors</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><issn>1742-2094</issn><issn>1742-2094</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkU1PHiEUhUnTplrbH-DGTNJNN2MvDJ8uTIzph4lJN-2aUAZGlIFXmDHx38ub11ptGhZw4TkHLgehQwzHGEv-uWKiBO0B8x44iJ6_QvtYUNITUPT1s_UeelfrNcBAGCdv0R4RhAtgah-pi7S4Et16E1LPTzqTOje7MoU0dcVNazRLLl323cYsVznmKVgTWxHSe_TGm1jdh8f5AP36-uXn-ff-8se3i_Ozy94ySpbeD0A4NYOlCjiWhLPRYCHF4EEqRgfvuWDUSSpgoJi1N3oqGRkxCGtGD8MBOt35btbfsxutS0sxUW9KmE2519kE_fIkhSs95TtNpRIKq2bw6dGg5NvV1UXPoVoXo0kur1VjoZjkmBLS0I__oNd5Lam1p7EEEJIyLv9Sk4lOh-Rzu9duTfUZ5VIKRgRt1PF_qDZGNwebk_Oh7b8Q4J3Allxrcf6pRwx6m7fe5a1b3nqbt-ZNc_T8c54UfwIeHgAmLKJD</recordid><startdate>20160607</startdate><enddate>20160607</enddate><creator>Zhou, Ya-Qun</creator><creator>Liu, Zheng</creator><creator>Liu, Zhi-Heng</creator><creator>Chen, Shu-Ping</creator><creator>Li, Man</creator><creator>Shahveranov, Allahverdi</creator><creator>Ye, Da-Wei</creator><creator>Tian, Yu-Ke</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160607</creationdate><title>Interleukin-6: an emerging regulator of pathological pain</title><author>Zhou, Ya-Qun ; Liu, Zheng ; Liu, Zhi-Heng ; Chen, Shu-Ping ; Li, Man ; Shahveranov, Allahverdi ; Ye, Da-Wei ; Tian, Yu-Ke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-f30264a3c490618265da17873f089543ff6754e84703415003f4852d107cadf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Chemotherapy</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - physiology</topic><topic>Interleukin-6 - toxicity</topic><topic>Pain</topic><topic>Pain - chemically induced</topic><topic>Pain - metabolism</topic><topic>Pain - pathology</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Measurement - methods</topic><topic>Review</topic><topic>Risk factors</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Ya-Qun</creatorcontrib><creatorcontrib>Liu, Zheng</creatorcontrib><creatorcontrib>Liu, Zhi-Heng</creatorcontrib><creatorcontrib>Chen, Shu-Ping</creatorcontrib><creatorcontrib>Li, Man</creatorcontrib><creatorcontrib>Shahveranov, Allahverdi</creatorcontrib><creatorcontrib>Ye, Da-Wei</creatorcontrib><creatorcontrib>Tian, Yu-Ke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroinflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Ya-Qun</au><au>Liu, Zheng</au><au>Liu, Zhi-Heng</au><au>Chen, Shu-Ping</au><au>Li, Man</au><au>Shahveranov, Allahverdi</au><au>Ye, Da-Wei</au><au>Tian, Yu-Ke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6: an emerging regulator of pathological pain</atitle><jtitle>Journal of neuroinflammation</jtitle><addtitle>J Neuroinflammation</addtitle><date>2016-06-07</date><risdate>2016</risdate><volume>13</volume><issue>1</issue><spage>141</spage><epage>141</epage><pages>141-141</pages><artnum>141</artnum><issn>1742-2094</issn><eissn>1742-2094</eissn><abstract>Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27267059</pmid><doi>10.1186/s12974-016-0607-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Chemotherapy Health aspects Humans Interleukin-6 Interleukin-6 - physiology Interleukin-6 - toxicity Pain Pain - chemically induced Pain - metabolism Pain - pathology Pain Measurement - drug effects Pain Measurement - methods Review Risk factors Signal Transduction - drug effects Signal Transduction - physiology |
| title | Interleukin-6: an emerging regulator of pathological pain |
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