Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a target-centered functional screen, we match...

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Veröffentlicht in:	Developmental cell 2016-03, Vol.36 (6), p.611-623
Hauptverfasser:	Ecco, Gabriela, Cassano, Marco, Kauzlaric, Annamaria, Duc, Julien, Coluccio, Andrea, Offner, Sandra, Imbeault, Michaël, Rowe, Helen M., Turelli, Priscilla, Trono, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Differentiation DNA Transposable Elements - genetics Embryonic Stem Cells - metabolism Endogenous Retroviruses - genetics Endogenous Retroviruses - metabolism Gene Expression Regulation Humans Mice Mice, Knockout Molecular Sequence Data Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Repressor Proteins - deficiency Repressor Proteins - genetics Repressor Proteins - metabolism Tripartite Motif-Containing Protein 28 Zinc Fingers - genetics
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