Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy re...

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Veröffentlicht in:	Scientific reports 2015-02, Vol.5 (1), p.8543-8543, Article 8543
Hauptverfasser:	Cashin, Kieran, Gray, Lachlan R., Harvey, Katherine L., Perez-Bercoff, Danielle, Lee, Guinevere Q., Sterjovski, Jasminka, Roche, Michael, Demarest, James F., Drummond, Fraser, Harrigan, P. Richard, Churchill, Melissa J., Gorry, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	49 49/56 631/250/2499 631/326/596/2555 Algorithms Amino Acid Sequence Antiretroviral agents Antiretroviral drugs Antiviral agents At risk populations CCR5 protein CCR5 Receptor Antagonists - therapeutic use Computational Biology Cyclohexanes - therapeutic use Genotype HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism HIV Infections - drug therapy HIV-1 - physiology Humanities and Social Sciences Humans Life Sciences multidisciplinary Mutation Pandemics Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Phenotype Receptors, CCR5 - chemistry Receptors, CCR5 - metabolism Science Triazoles - therapeutic use Tropism Viral Tropism - genetics
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