Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels

Nicotinic acid (NA, a.k.a. vitamin B3 or niacin) can reduce blood cholesterol and low-density lipoproteins whereas increase high-density lipoproteins. However, when NA is used to treat dyslipidemias, it causes a strong side effect of cutaneous vasodilation, commonly called flushing. A recent study s...

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Veröffentlicht in:	Scientific reports 2015-03, Vol.5 (1), p.8906-8906, Article 8906
Hauptverfasser:	Ma, Linlin, Lee, Bo Hyun, Clifton, Heather, Schaefer, Saul, Zheng, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 631/443/1338/1872 692/699/75/2099 9/74 Body temperature Body Temperature - drug effects Body Temperature - genetics Boron Compounds - administration & dosage Boron Compounds - metabolism Calcium Channels - biosynthesis Calcium Channels - genetics Capsaicin Capsaicin receptors Channel gating Cholesterol Flushing Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Gene Expression Regulation - drug effects Heat HEK293 Cells Humanities and Social Sciences Humans Ion channels Keratinocytes Lipoproteins Low density lipoprotein Metabolic Networks and Pathways - drug effects multidisciplinary Niacin - administration & dosage Niacin - adverse effects Nicotinic acid Patch-Clamp Techniques Science Skin Skin - drug effects Skin - metabolism Skin - pathology Temperature effects TRPV Cation Channels - biosynthesis TRPV Cation Channels - genetics Vasodilation
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