Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

We have generated a strain of mice lacking two DNA N-glycosylases of base excision repair (BER), NTH1 and NEIL1, homologs of bacterial Nth (endonuclease three) and Nei (endonuclease eight). Although these enzymes remove several oxidized bases from DNA, they do not remove the well-known carcinogenic...

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Veröffentlicht in:	DNA repair 2009-07, Vol.8 (7), p.786-794
Hauptverfasser:	Chan, Michael K., Ocampo-Hafalla, Maria T., Vartanian, Vladimir, Jaruga, Pawel, Kirkali, Güldal, Koenig, Karen L., Brown, Stuart, Lloyd, R. Stephen, Dizdaroglu, Miral, Teebor, George W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Base excision repair Base Sequence Biological and medical sciences Brain - metabolism Brain - pathology Cancer Deoxyribonuclease (Pyrimidine Dimer) - genetics Deoxyribonuclease (Pyrimidine Dimer) - metabolism DNA Damage DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA Mutational Analysis Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Gene Deletion Genes, ras - genetics Growth, nutrition, cell differenciation Guanine - analogs & derivatives Guanine - metabolism K-ras Kidney - metabolism Kidney - pathology Liver - metabolism Liver - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Microbiology Molecular and cellular biology Molecular genetics Mouse Mutagenesis. Repair Mutation NEIL1 NTH1 Oxidation-Reduction Pyrimidines - metabolism
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