Anti-Schistosoma IgG responses in Schistosoma haematobium single and concomitant infection with malaria parasites
Areas prone to schistosomiasis are also at risk of malaria transmission. The interaction between the causal agents of the two diseases could modulate immune responses tailored toward protecting or aggravating morbidity dynamics and impair Schistosoma diagnostic precision. This study aimed at assessi...
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| Veröffentlicht in: | Pathogens and global health 2016-03, Vol.110 (2), p.74-78 |
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| creator | Morenikeji, Olajumoke A. Adeleye, Olumide Omoruyi, Ewean C. Oyeyemi, Oyetunde T. |
| description | Areas prone to schistosomiasis are also at risk of malaria transmission. The interaction between the causal agents of the two diseases could modulate immune responses tailored toward protecting or aggravating morbidity dynamics and impair Schistosoma diagnostic precision. This study aimed at assessing the effect of Plasmodium spp. in concomitant infection with Schistosoma haematobium in modulation of anti-Schistosoma IgG antibodies. The school-based cross-sectional study recruited a total of 322 children screened for S. haematobium and Plasmodium spp. Levels of IgG against S. haematobium-soluble egg antigen (SEA) in single S. haematobium/malaria parasites infection and co-infection of the two parasites in schoolchildren were determined. Data were analyzed using χ
2
, Fisher's exact test, and Tukey's multiple comparison test analyses. The prevalence of single infection by S. haematobium, Plasmodium spp., and concurrent infection due to the two pathogens was 27.7, 41.0, and 9.3%, respectively (p |
| doi_str_mv | 10.1080/20477724.2016.1174499 |
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2
, Fisher's exact test, and Tukey's multiple comparison test analyses. The prevalence of single infection by S. haematobium, Plasmodium spp., and concurrent infection due to the two pathogens was 27.7, 41.0, and 9.3%, respectively (p < 0.0001). Anti-Schistosoma IgG production during co-infection of the two pathogens (1.950 ± 0.742 AU) was significantly higher than the value recorded for single malaria parasites' infection (1.402 ± 0.670 AU) (p < 0.01) but not in S. haematobium infection (1.591 ± 0.604 AU) (p > 0.05). The anti-Schistosoma IgG production in co-infection status was however dependent on the intensity of Plasmodium spp. with individuals having high intensity of malaria parasites recording lower anti-Schistosoma IgG. This study has implication for diagnosis of schistosomiasis where anti-Schistosoma IgG is used as an indicator of infection. Efforts should be made to control the two infections simultaneously in order not to undermine the efforts targeted toward the control of one.</description><identifier>ISSN: 2047-7724</identifier><identifier>EISSN: 2047-7732</identifier><identifier>DOI: 10.1080/20477724.2016.1174499</identifier><identifier>PMID: 27092873</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adolescent ; Animals ; Anti-Schistosoma antibodies ; Antibodies, Protozoan - biosynthesis ; Antibodies, Protozoan - blood ; Antibody Specificity ; Child ; Child, Preschool ; Children ; Co-infection ; Coinfection ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - blood ; Malaria ; Malaria - complications ; Malaria - epidemiology ; Malaria - parasitology ; Male ; Nigeria - epidemiology ; Original ; Plasmodium - immunology ; Plasmodium - isolation & purification ; Prevalence ; Schistosoma haematobium - immunology ; Schistosoma haematobium - isolation & purification ; Schistosomiasis ; Schistosomiasis haematobia - complications ; Schistosomiasis haematobia - epidemiology ; Schistosomiasis haematobia - immunology ; Young Adult</subject><ispartof>Pathogens and global health, 2016-03, Vol.110 (2), p.74-78</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6fe43649398aa3dcbb01561e7b5849677c583f9c014522126b53336d1f8fdfcb3</citedby><cites>FETCH-LOGICAL-c421t-6fe43649398aa3dcbb01561e7b5849677c583f9c014522126b53336d1f8fdfcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894265/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894265/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27092873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morenikeji, Olajumoke A.</creatorcontrib><creatorcontrib>Adeleye, Olumide</creatorcontrib><creatorcontrib>Omoruyi, Ewean C.</creatorcontrib><creatorcontrib>Oyeyemi, Oyetunde T.</creatorcontrib><title>Anti-Schistosoma IgG responses in Schistosoma haematobium single and concomitant infection with malaria parasites</title><title>Pathogens and global health</title><addtitle>Pathog Glob Health</addtitle><description>Areas prone to schistosomiasis are also at risk of malaria transmission. The interaction between the causal agents of the two diseases could modulate immune responses tailored toward protecting or aggravating morbidity dynamics and impair Schistosoma diagnostic precision. This study aimed at assessing the effect of Plasmodium spp. in concomitant infection with Schistosoma haematobium in modulation of anti-Schistosoma IgG antibodies. The school-based cross-sectional study recruited a total of 322 children screened for S. haematobium and Plasmodium spp. Levels of IgG against S. haematobium-soluble egg antigen (SEA) in single S. haematobium/malaria parasites infection and co-infection of the two parasites in schoolchildren were determined. Data were analyzed using χ
2
, Fisher's exact test, and Tukey's multiple comparison test analyses. The prevalence of single infection by S. haematobium, Plasmodium spp., and concurrent infection due to the two pathogens was 27.7, 41.0, and 9.3%, respectively (p < 0.0001). Anti-Schistosoma IgG production during co-infection of the two pathogens (1.950 ± 0.742 AU) was significantly higher than the value recorded for single malaria parasites' infection (1.402 ± 0.670 AU) (p < 0.01) but not in S. haematobium infection (1.591 ± 0.604 AU) (p > 0.05). The anti-Schistosoma IgG production in co-infection status was however dependent on the intensity of Plasmodium spp. with individuals having high intensity of malaria parasites recording lower anti-Schistosoma IgG. This study has implication for diagnosis of schistosomiasis where anti-Schistosoma IgG is used as an indicator of infection. Efforts should be made to control the two infections simultaneously in order not to undermine the efforts targeted toward the control of one.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Anti-Schistosoma antibodies</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antibody Specificity</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Co-infection</subject><subject>Coinfection</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Malaria</subject><subject>Malaria - complications</subject><subject>Malaria - epidemiology</subject><subject>Malaria - parasitology</subject><subject>Male</subject><subject>Nigeria - epidemiology</subject><subject>Original</subject><subject>Plasmodium - immunology</subject><subject>Plasmodium - isolation & purification</subject><subject>Prevalence</subject><subject>Schistosoma haematobium - immunology</subject><subject>Schistosoma haematobium - isolation & purification</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis haematobia - complications</subject><subject>Schistosomiasis haematobia - epidemiology</subject><subject>Schistosomiasis haematobia - immunology</subject><subject>Young Adult</subject><issn>2047-7724</issn><issn>2047-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EolXpRwD5yGWD_629viCqqpRKlTgAZ2vWaydGazu1Hap-ezZKGpULvtiaee_NyD-E3lOyomQgnxgRSikmVoxQuaJUCaH1K3S-r3dKcfb69GbiDF3W-pssR_ZUMfYWnTFFNBsUP0cPV6mF7ofdhNpyzRHw3foWF1e3OVVXcUj4ZXMDLkLLY9hFXENazw5DmrDNyeYYGqS2OLyzLeSEH0Pb4AgzlAB4CwVqaK6-Q288zNVdHu8L9Ovrzc_rb93999u766v7zgpGWye9E1wKzfUAwCc7joT2kjo19oPQUinbD9xrS6joGaNMjj3nXE7UD37yduQX6PMhd7sbo5usS63AbLYlRChPJkMw_3ZS2Jh1_mPEoAWT_RLw8RhQ8sPO1WZiqNbNMySXd9VQpTmjkrNhkfYHqS251uL8aQwlZk_MPBMze2LmSGzxfXi548n1zGcRfDkIll_NJcJjLvNkGjzNufgCyYZq-P9n_AWKmagE</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Morenikeji, Olajumoke A.</creator><creator>Adeleye, Olumide</creator><creator>Omoruyi, Ewean C.</creator><creator>Oyeyemi, Oyetunde T.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Anti-Schistosoma IgG responses in Schistosoma haematobium single and concomitant infection with malaria parasites</title><author>Morenikeji, Olajumoke A. ; Adeleye, Olumide ; Omoruyi, Ewean C. ; Oyeyemi, Oyetunde T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6fe43649398aa3dcbb01561e7b5849677c583f9c014522126b53336d1f8fdfcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Anti-Schistosoma antibodies</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antibody Specificity</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Co-infection</topic><topic>Coinfection</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Malaria</topic><topic>Malaria - complications</topic><topic>Malaria - epidemiology</topic><topic>Malaria - parasitology</topic><topic>Male</topic><topic>Nigeria - epidemiology</topic><topic>Original</topic><topic>Plasmodium - immunology</topic><topic>Plasmodium - isolation & purification</topic><topic>Prevalence</topic><topic>Schistosoma haematobium - immunology</topic><topic>Schistosoma haematobium - isolation & purification</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis haematobia - complications</topic><topic>Schistosomiasis haematobia - epidemiology</topic><topic>Schistosomiasis haematobia - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morenikeji, Olajumoke A.</creatorcontrib><creatorcontrib>Adeleye, Olumide</creatorcontrib><creatorcontrib>Omoruyi, Ewean C.</creatorcontrib><creatorcontrib>Oyeyemi, Oyetunde T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathogens and global health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morenikeji, Olajumoke A.</au><au>Adeleye, Olumide</au><au>Omoruyi, Ewean C.</au><au>Oyeyemi, Oyetunde T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Schistosoma IgG responses in Schistosoma haematobium single and concomitant infection with malaria parasites</atitle><jtitle>Pathogens and global health</jtitle><addtitle>Pathog Glob Health</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>110</volume><issue>2</issue><spage>74</spage><epage>78</epage><pages>74-78</pages><issn>2047-7724</issn><eissn>2047-7732</eissn><abstract>Areas prone to schistosomiasis are also at risk of malaria transmission. The interaction between the causal agents of the two diseases could modulate immune responses tailored toward protecting or aggravating morbidity dynamics and impair Schistosoma diagnostic precision. This study aimed at assessing the effect of Plasmodium spp. in concomitant infection with Schistosoma haematobium in modulation of anti-Schistosoma IgG antibodies. The school-based cross-sectional study recruited a total of 322 children screened for S. haematobium and Plasmodium spp. Levels of IgG against S. haematobium-soluble egg antigen (SEA) in single S. haematobium/malaria parasites infection and co-infection of the two parasites in schoolchildren were determined. Data were analyzed using χ
2
, Fisher's exact test, and Tukey's multiple comparison test analyses. The prevalence of single infection by S. haematobium, Plasmodium spp., and concurrent infection due to the two pathogens was 27.7, 41.0, and 9.3%, respectively (p < 0.0001). Anti-Schistosoma IgG production during co-infection of the two pathogens (1.950 ± 0.742 AU) was significantly higher than the value recorded for single malaria parasites' infection (1.402 ± 0.670 AU) (p < 0.01) but not in S. haematobium infection (1.591 ± 0.604 AU) (p > 0.05). The anti-Schistosoma IgG production in co-infection status was however dependent on the intensity of Plasmodium spp. with individuals having high intensity of malaria parasites recording lower anti-Schistosoma IgG. This study has implication for diagnosis of schistosomiasis where anti-Schistosoma IgG is used as an indicator of infection. Efforts should be made to control the two infections simultaneously in order not to undermine the efforts targeted toward the control of one.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27092873</pmid><doi>10.1080/20477724.2016.1174499</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Animals Anti-Schistosoma antibodies Antibodies, Protozoan - biosynthesis Antibodies, Protozoan - blood Antibody Specificity Child Child, Preschool Children Co-infection Coinfection Cross-Sectional Studies Female Humans Immunoglobulin G - biosynthesis Immunoglobulin G - blood Malaria Malaria - complications Malaria - epidemiology Malaria - parasitology Male Nigeria - epidemiology Original Plasmodium - immunology Plasmodium - isolation & purification Prevalence Schistosoma haematobium - immunology Schistosoma haematobium - isolation & purification Schistosomiasis Schistosomiasis haematobia - complications Schistosomiasis haematobia - epidemiology Schistosomiasis haematobia - immunology Young Adult |
| title | Anti-Schistosoma IgG responses in Schistosoma haematobium single and concomitant infection with malaria parasites |
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