Role of Telomeres and Telomerase in Aging and Cancer

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is the ability for continuous cell divisions that almost universally correlates with the stabilization of telomere length by the reactivation of telomerase. The repression of telomerase and shorter telomeres in huma...

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Veröffentlicht in:	Cancer discovery 2016-06, Vol.6 (6), p.584-593
1. Verfasser:	Shay, Jerry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Animals Apoptosis Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Humans Neoplasms - genetics Neoplasms - metabolism Telomerase - metabolism Telomere - genetics Telomere - metabolism Telomere Homeostasis Telomere Shortening
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