The Nucleoside Uridine Isolated in the Gas Phase
Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐endo‐g+ conformation has been reveale...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2015-03, Vol.54 (10), p.2991-2994 |
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| creator | Peña, Isabel Cabezas, Carlos Alonso, José L. |
| description | Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐endo‐g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.
Intramolecular hydrogen bonds: The simplest nucleoside uridine has been placed in the gas phase by laser ablation and structurally characterized by Fourier transform microwave spectroscopy. Intramolecular hydrogen bonds involving uracil and ribose moieties (see picture) have been found to play an important role in the stabilization of the nucleoside. |
| doi_str_mv | 10.1002/anie.201412460 |
| format | Article |
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Intramolecular hydrogen bonds: The simplest nucleoside uridine has been placed in the gas phase by laser ablation and structurally characterized by Fourier transform microwave spectroscopy. Intramolecular hydrogen bonds involving uracil and ribose moieties (see picture) have been found to play an important role in the stabilization of the nucleoside.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201412460</identifier><identifier>PMID: 25683559</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>conformational analysis ; Fourier transforms ; Gas phases ; Gases - chemistry ; Hydrogen bonds ; Laser ablation ; microwave spectroscopy ; Nucleosides ; Ribose ; Stabilization ; Uracil ; Uridine - chemistry ; Uridine - isolation & purification</subject><ispartof>Angewandte Chemie International Edition, 2015-03, Vol.54 (10), p.2991-2994</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6090-f18004fad1dd33d2a3873c03ab2641e19f457f4f6cbc6940f7b1226783e50cf3</citedby><cites>FETCH-LOGICAL-c6090-f18004fad1dd33d2a3873c03ab2641e19f457f4f6cbc6940f7b1226783e50cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201412460$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201412460$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25683559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peña, Isabel</creatorcontrib><creatorcontrib>Cabezas, Carlos</creatorcontrib><creatorcontrib>Alonso, José L.</creatorcontrib><title>The Nucleoside Uridine Isolated in the Gas Phase</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐endo‐g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.
Intramolecular hydrogen bonds: The simplest nucleoside uridine has been placed in the gas phase by laser ablation and structurally characterized by Fourier transform microwave spectroscopy. Intramolecular hydrogen bonds involving uracil and ribose moieties (see picture) have been found to play an important role in the stabilization of the nucleoside.</description><subject>conformational analysis</subject><subject>Fourier transforms</subject><subject>Gas phases</subject><subject>Gases - chemistry</subject><subject>Hydrogen bonds</subject><subject>Laser ablation</subject><subject>microwave spectroscopy</subject><subject>Nucleosides</subject><subject>Ribose</subject><subject>Stabilization</subject><subject>Uracil</subject><subject>Uridine - chemistry</subject><subject>Uridine - isolation & purification</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgiq3Vq0cZ8NLLrHnzPRehLHVdKKvCSo8hm3njps7O1GRG7X9vlq1L9dJTAvm9D0keQl4DnQGl7J3rI84YBQFMKPqEnIJkUHOt-dOyF5zX2kg4IS9yvineGKqekxMmleFSNqeErrdYrSbf4ZBji9XXFNvYY7XMQ-dGbKvYV2MhC5erz1uX8SV5FlyX8dX9ekbWHy7X84_11afFcn5xVXtFG1oHMJSK4FpoW85b5rjR3FPuNkwJQGiCkDqIoPzGq0bQoDfAmNKGo6Q-8DPy_hB7O2122Hrsx-Q6e5vizqU7O7ho_z3p49Z-G35aYRrGhSwB5_cBafgxYR7tLmaPXed6HKZsQVPaGA6aP06VNAI0a3Shb_-jN8OU-vIRe6WlMGBYUbOD8mnIOWE43huo3ddm97XZY21l4M3D1x75354KaA7gV-zw7pE4e7FaXj4Mrw-zMY_4-zjr0nerNNfSXq8Wdn5t5l-kUlbzPzfJsLQ</recordid><startdate>20150302</startdate><enddate>20150302</enddate><creator>Peña, Isabel</creator><creator>Cabezas, Carlos</creator><creator>Alonso, José L.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>5PM</scope></search><sort><creationdate>20150302</creationdate><title>The Nucleoside Uridine Isolated in the Gas Phase</title><author>Peña, Isabel ; Cabezas, Carlos ; Alonso, José L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6090-f18004fad1dd33d2a3873c03ab2641e19f457f4f6cbc6940f7b1226783e50cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>conformational analysis</topic><topic>Fourier transforms</topic><topic>Gas phases</topic><topic>Gases - chemistry</topic><topic>Hydrogen bonds</topic><topic>Laser ablation</topic><topic>microwave spectroscopy</topic><topic>Nucleosides</topic><topic>Ribose</topic><topic>Stabilization</topic><topic>Uracil</topic><topic>Uridine - chemistry</topic><topic>Uridine - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peña, Isabel</creatorcontrib><creatorcontrib>Cabezas, Carlos</creatorcontrib><creatorcontrib>Alonso, José L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peña, Isabel</au><au>Cabezas, Carlos</au><au>Alonso, José L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Nucleoside Uridine Isolated in the Gas Phase</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2015-03-02</date><risdate>2015</risdate><volume>54</volume><issue>10</issue><spage>2991</spage><epage>2994</epage><pages>2991-2994</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐endo‐g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.
Intramolecular hydrogen bonds: The simplest nucleoside uridine has been placed in the gas phase by laser ablation and structurally characterized by Fourier transform microwave spectroscopy. Intramolecular hydrogen bonds involving uracil and ribose moieties (see picture) have been found to play an important role in the stabilization of the nucleoside.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>25683559</pmid><doi>10.1002/anie.201412460</doi><tpages>4</tpages><edition>International ed. in English</edition><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | conformational analysis Fourier transforms Gas phases Gases - chemistry Hydrogen bonds Laser ablation microwave spectroscopy Nucleosides Ribose Stabilization Uracil Uridine - chemistry Uridine - isolation & purification |
| title | The Nucleoside Uridine Isolated in the Gas Phase |
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