Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling

Striatal gene expression correlates with reduction in ethanol consumption due to wheel running. Hedonic substitution, where wheel running reduces voluntary ethanol consumption, has been observed in prior studies. Here, we replicate and expand on previous work showing that mice decrease voluntary eth...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2016-06, Vol.15 (5), p.474-490
Hauptverfasser:	Darlington, T. M., McCarthy, R. D., Cox, R. J., Miyamoto‐Ditmon, J., Gallego, X., Ehringer, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alcohol Drinking - genetics Animals Calmodulin-Binding Proteins - metabolism Corpus Striatum - metabolism Corpus Striatum - physiology edgeR Ethanol ethanol consumption ethanol preference Female GABA Plasma Membrane Transport Proteins - genetics GABA Plasma Membrane Transport Proteins - metabolism Gene expression Gene Regulatory Networks hedonic substitution loss of righting reflex Mice Mice, Inbred C57BL Munc18 Proteins - genetics Munc18 Proteins - metabolism Physical Exertion - genetics Potassium Channels - genetics Potassium Channels - metabolism Proprotein Convertases - genetics Proprotein Convertases - metabolism Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism RNA‐Seq Running striatum Studies Syntaxin 1 - genetics Syntaxin 1 - metabolism tophat Trans-Activators - metabolism Transcriptome WGCNA wheel running
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