Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice

This study aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model. We chose six gastric mucosal protectants (ecabet sodium hydrate, irsogladine maleate, rebamipide, sofalcone, teprenone and troxipide) and examined their effects on the activity of oxidat...

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Veröffentlicht in:	Oncotarget 2016-02, Vol.7 (8), p.8640-8652
Hauptverfasser:	Onuma, Wakana, Tomono, Susumu, Miyamoto, Shinngo, Fujii, Gen, Hamoya, Takahiro, Fujimoto, Kyoko, Miyoshi, Noriyuki, Fukai, Fumio, Wakabayashi, Keiji, Mutoh, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - pharmacology Apoptosis - drug effects Blotting, Western Cell Proliferation - drug effects Cells, Cultured Disease Models, Animal Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Genes, APC - physiology Humans Immunoenzyme Techniques Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Intestinal Polyps - pathology Intestinal Polyps - prevention & control Male Mice Mice, Inbred C57BL Mutation - genetics Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction - drug effects Triazines - pharmacology
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