Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria
Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, trea...
Gespeichert in:
| Veröffentlicht in: | ISRN Parasitology 2013-08, Vol.2013, p.960168-10 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | |
| container_start_page | 960168 |
| container_title | ISRN Parasitology |
| container_volume | 2013 |
| creator | Osue, Hudu O. Inabo, Helen I. Yakubu, Sabo E. Audu, Patrick A. Galadima, Musa Odama, Lillian E. Musa, Danjuma Ado, Saleh A. Mamman, Mohammed |
| description | Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P |
| doi_str_mv | 10.5402/2013/960168 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4890928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1803452216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2618-560da5045d330d780a98dce0899e97ed7596bd6be5a5534740400c8f191de5103</originalsourceid><addsrcrecordid>eNp9kUFrFDEUxwdRbKk9eZccRRmbTCYzyUUoS9WlxR62Cp7C2-TtTmQmsyaZLf0q_bRm2LbUiyGQR_J7vzz4F8VbRj-JmlZnFWX8TDWUNfJFcVxxVpc1bZuXz-qj4jTG3zQvpSSX_HVxVLV8Lpvj4n457MAkMm7Ihdt2CdGXvxAC-QnBoSWLcdj1DrxBkkZy7U03GgzGQXSR3ASENKBP5Naljiz3GAY0yXmS9yrfO489WcEevIeOnG9DloKfpcPkXXIYZ_IS7OSBrBIknAf57raYuTfFqw30EU8fzpPix5eLm8W38ur663JxflWaqmGyFA21IGgtLOfUtpKCktYglUqhatG2QjVr26xRgBC8bmtaU2rkhilmUTDKT4rPB-9uWg-YW30K0OtdcAOEOz2C0_--eNfp7bjXtVRUVTIL3j8Iwvhnwpj04KLBvgeP4xQ1k5TXoqpYk9GPB9SEMcaAm6dvGNVzoHoOVB8CzfS755M9sY_xZeDDAeict3Dr_mv7C3sBqfU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1803452216</pqid></control><display><type>article</type><title>Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Osue, Hudu O. ; Inabo, Helen I. ; Yakubu, Sabo E. ; Audu, Patrick A. ; Galadima, Musa ; Odama, Lillian E. ; Musa, Danjuma ; Ado, Saleh A. ; Mamman, Mohammed</creator><contributor>Dash, A. P. ; Kalyanasundaram, R.</contributor><creatorcontrib>Osue, Hudu O. ; Inabo, Helen I. ; Yakubu, Sabo E. ; Audu, Patrick A. ; Galadima, Musa ; Odama, Lillian E. ; Musa, Danjuma ; Ado, Saleh A. ; Mamman, Mohammed ; Dash, A. P. ; Kalyanasundaram, R.</creatorcontrib><description>Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P<0.05, (t-test of unpaired data). Cases of glaucoma, 8 (1.4%), and blindness, 6 (1.05%), remained unchanged. Visual acuity ≥6/24 in one or both eyes, 198 (33.45%); cataract, 169 (28.5%); pterygium 157 (26.5%); and acute senilis, 165 (27.9%), were significantly increased and positively correlated with increase in age (R2=0.898−0.949). Dissected parous Simulium damnosum caught (n=222) were without infective third stage larva. Active onchocerciasis transmission seems halted despite varied compliance to long-term ivermectin treatment. We recommend continued surveillance and targeted treatment of controlled and hypoendemic areas.</description><identifier>ISSN: 2314-4076</identifier><identifier>EISSN: 2314-4076</identifier><identifier>DOI: 10.5402/2013/960168</identifier><identifier>PMID: 27398386</identifier><language>eng</language><publisher>United States: Hindawi Publishing Corporation</publisher><ispartof>ISRN Parasitology, 2013-08, Vol.2013, p.960168-10</ispartof><rights>Copyright © 2013 Hudu O. Osue et al.</rights><rights>Copyright © 2013 Hudu O. Osue et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2618-560da5045d330d780a98dce0899e97ed7596bd6be5a5534740400c8f191de5103</citedby><cites>FETCH-LOGICAL-c2618-560da5045d330d780a98dce0899e97ed7596bd6be5a5534740400c8f191de5103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890928/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890928/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27398386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dash, A. P.</contributor><contributor>Kalyanasundaram, R.</contributor><creatorcontrib>Osue, Hudu O.</creatorcontrib><creatorcontrib>Inabo, Helen I.</creatorcontrib><creatorcontrib>Yakubu, Sabo E.</creatorcontrib><creatorcontrib>Audu, Patrick A.</creatorcontrib><creatorcontrib>Galadima, Musa</creatorcontrib><creatorcontrib>Odama, Lillian E.</creatorcontrib><creatorcontrib>Musa, Danjuma</creatorcontrib><creatorcontrib>Ado, Saleh A.</creatorcontrib><creatorcontrib>Mamman, Mohammed</creatorcontrib><title>Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria</title><title>ISRN Parasitology</title><addtitle>ISRN Parasitol</addtitle><description>Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P<0.05, (t-test of unpaired data). Cases of glaucoma, 8 (1.4%), and blindness, 6 (1.05%), remained unchanged. Visual acuity ≥6/24 in one or both eyes, 198 (33.45%); cataract, 169 (28.5%); pterygium 157 (26.5%); and acute senilis, 165 (27.9%), were significantly increased and positively correlated with increase in age (R2=0.898−0.949). Dissected parous Simulium damnosum caught (n=222) were without infective third stage larva. Active onchocerciasis transmission seems halted despite varied compliance to long-term ivermectin treatment. We recommend continued surveillance and targeted treatment of controlled and hypoendemic areas.</description><issn>2314-4076</issn><issn>2314-4076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNp9kUFrFDEUxwdRbKk9eZccRRmbTCYzyUUoS9WlxR62Cp7C2-TtTmQmsyaZLf0q_bRm2LbUiyGQR_J7vzz4F8VbRj-JmlZnFWX8TDWUNfJFcVxxVpc1bZuXz-qj4jTG3zQvpSSX_HVxVLV8Lpvj4n457MAkMm7Ihdt2CdGXvxAC-QnBoSWLcdj1DrxBkkZy7U03GgzGQXSR3ASENKBP5Naljiz3GAY0yXmS9yrfO489WcEevIeOnG9DloKfpcPkXXIYZ_IS7OSBrBIknAf57raYuTfFqw30EU8fzpPix5eLm8W38ur663JxflWaqmGyFA21IGgtLOfUtpKCktYglUqhatG2QjVr26xRgBC8bmtaU2rkhilmUTDKT4rPB-9uWg-YW30K0OtdcAOEOz2C0_--eNfp7bjXtVRUVTIL3j8Iwvhnwpj04KLBvgeP4xQ1k5TXoqpYk9GPB9SEMcaAm6dvGNVzoHoOVB8CzfS755M9sY_xZeDDAeict3Dr_mv7C3sBqfU</recordid><startdate>20130825</startdate><enddate>20130825</enddate><creator>Osue, Hudu O.</creator><creator>Inabo, Helen I.</creator><creator>Yakubu, Sabo E.</creator><creator>Audu, Patrick A.</creator><creator>Galadima, Musa</creator><creator>Odama, Lillian E.</creator><creator>Musa, Danjuma</creator><creator>Ado, Saleh A.</creator><creator>Mamman, Mohammed</creator><general>Hindawi Publishing Corporation</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130825</creationdate><title>Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria</title><author>Osue, Hudu O. ; Inabo, Helen I. ; Yakubu, Sabo E. ; Audu, Patrick A. ; Galadima, Musa ; Odama, Lillian E. ; Musa, Danjuma ; Ado, Saleh A. ; Mamman, Mohammed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2618-560da5045d330d780a98dce0899e97ed7596bd6be5a5534740400c8f191de5103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osue, Hudu O.</creatorcontrib><creatorcontrib>Inabo, Helen I.</creatorcontrib><creatorcontrib>Yakubu, Sabo E.</creatorcontrib><creatorcontrib>Audu, Patrick A.</creatorcontrib><creatorcontrib>Galadima, Musa</creatorcontrib><creatorcontrib>Odama, Lillian E.</creatorcontrib><creatorcontrib>Musa, Danjuma</creatorcontrib><creatorcontrib>Ado, Saleh A.</creatorcontrib><creatorcontrib>Mamman, Mohammed</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ISRN Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osue, Hudu O.</au><au>Inabo, Helen I.</au><au>Yakubu, Sabo E.</au><au>Audu, Patrick A.</au><au>Galadima, Musa</au><au>Odama, Lillian E.</au><au>Musa, Danjuma</au><au>Ado, Saleh A.</au><au>Mamman, Mohammed</au><au>Dash, A. P.</au><au>Kalyanasundaram, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria</atitle><jtitle>ISRN Parasitology</jtitle><addtitle>ISRN Parasitol</addtitle><date>2013-08-25</date><risdate>2013</risdate><volume>2013</volume><spage>960168</spage><epage>10</epage><pages>960168-10</pages><issn>2314-4076</issn><eissn>2314-4076</eissn><abstract>Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P<0.05, (t-test of unpaired data). Cases of glaucoma, 8 (1.4%), and blindness, 6 (1.05%), remained unchanged. Visual acuity ≥6/24 in one or both eyes, 198 (33.45%); cataract, 169 (28.5%); pterygium 157 (26.5%); and acute senilis, 165 (27.9%), were significantly increased and positively correlated with increase in age (R2=0.898−0.949). Dissected parous Simulium damnosum caught (n=222) were without infective third stage larva. Active onchocerciasis transmission seems halted despite varied compliance to long-term ivermectin treatment. We recommend continued surveillance and targeted treatment of controlled and hypoendemic areas.</abstract><cop>United States</cop><pub>Hindawi Publishing Corporation</pub><pmid>27398386</pmid><doi>10.5402/2013/960168</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-4076 |
| ispartof | ISRN Parasitology, 2013-08, Vol.2013, p.960168-10 |
| issn | 2314-4076 2314-4076 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4890928 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| title | Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T16%3A08%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Eighteen-Year%20Varied%20Compliance%20to%20Onchocerciasis%20Treatment%20with%20Ivermectin%20in%20Sentinel%20Savannah%20Agrarian%20Communities%20in%20Kaduna%20State%20of%20Nigeria&rft.jtitle=ISRN%20Parasitology&rft.au=Osue,%20Hudu%20O.&rft.date=2013-08-25&rft.volume=2013&rft.spage=960168&rft.epage=10&rft.pages=960168-10&rft.issn=2314-4076&rft.eissn=2314-4076&rft_id=info:doi/10.5402/2013/960168&rft_dat=%3Cproquest_pubme%3E1803452216%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1803452216&rft_id=info:pmid/27398386&rfr_iscdi=true |