Flt1/VEGFR1 heterozygosity causes transient embryonic edema

Vascular endothelial growth factor-A is a major player in vascular development and a potent vascular permeability factor under physiological and pathological conditions by binding to a decoy receptor Flt1 and its primary receptor Flk1. In this study, we show that Flt1 heterozygous ( Flt1 +/− ) mouse...

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Veröffentlicht in:	Scientific reports 2016-06, Vol.6 (1), p.27186-27186, Article 27186
Hauptverfasser:	Otowa, Yasunori, Moriwaki, Kazumasa, Sano, Keigo, Shirakabe, Masanori, Yonemura, Shigenobu, Shibuya, Masabumi, Rossant, Janet, Suda, Toshio, Kakeji, Yoshihiro, Hirashima, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 631/136/16 631/136/290 Adaptor Proteins, Signal Transducing - genetics Animals Capillary Permeability Cell Membrane - metabolism Edema - genetics Edema - metabolism Embryonic Development Endothelial Cells Genetic Heterogeneity Humanities and Social Sciences Mice multidisciplinary Mutation Nuchal Translucency Measurement Phosphorylation Science Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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