Expansion of myeloid-derived suppressor cells promotes differentiation of regulatory T cells in HIV-1+ individuals

OBJECTIVE:Regulatory T cells (Tregs) contribute to HIV-1 disease progression by impairing antiviral immunity; however, the precise mechanisms responsible for the development of Tregs in the setting of HIV-1 infection are incompletely understood. DESIGN:In this study, we provide evidence that HIV-ind...

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Veröffentlicht in:	AIDS (London) 2016-06, Vol.30 (10), p.1521-1531
Hauptverfasser:	Wang, Ling, Zhao, Juan, Ren, Jun P, Wu, Xiao Y, Morrison, Zheng D, El Gazzar, Mohamed, Ning, Shun B, Moorman, Jonathan P, Yao, Zhi Q
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Cell Differentiation Cells, Cultured Coculture Techniques Cytokines - biosynthesis Flow Cytometry Forkhead Transcription Factors - analysis HIV Infections - pathology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lentivirus Myeloid-Derived Suppressor Cells - physiology Retroviridae T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - physiology
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