Cdc45 is limiting for replication initiation in humans

Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as contr...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2016-01, Vol.15 (7), p.974-985
Hauptverfasser:	Köhler, Carsten, Koalick, Dennis, Fabricius, Anja, Parplys, Ann Christin, Borgmann, Kerstin, Pospiech, Helmut, Grosse, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Cycle Proteins - metabolism DNA Replication DNA, Single-Stranded - analysis HeLa Cells Histones - metabolism Humans Replication Origin S Phase Cell Cycle Checkpoints Signal Transduction
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