Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers
AbstractObjectiveExposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the ser...
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| Veröffentlicht in: | Schizophrenia research 2015-12, Vol.169 (1), p.10-15 |
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| creator | Fan, Ni Luo, Yayan Xu, Ke Zhang, Minling Ke, Xiaoyin Huang, Xini Ding, Yi Wang, Daping Ning, Yuping Deng, Xuefeng He, Hongbo |
| description | AbstractObjectiveExposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed. Methods155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS). ResultsSerum IL-6 and IL-18 levels were significantly higher, while serum TNF-α level was significantly lower among ketamine users than among healthy controls ( p< 0.05). Serum TNF-α levels showed a significant negative association with PANSS total score ( r= − 0.210, p< 0.01) and negative subscore ( r= − 0.300, p< 0.01). No significant association was found between PANSS score and serum levels of IL-6 and IL-18. ConclusionsSerum levels of TNF-α, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers. |
| doi_str_mv | 10.1016/j.schres.2015.11.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4888966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0920996415300499</els_id><sourcerecordid>1749991474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-93bb4c70020e11804f86463ef8b1345b86747df150531e4a557775909b00bc613</originalsourceid><addsrcrecordid>eNqFks9u1DAQxiMEokvhDRDKkQMJ48R27AsSqlqotAIJytlynAnr3cRe7GSl5a14EZ4Jhy3lz4WTx5qZ75vRb7LsKYGSAOEvt2U0m4CxrICwkpASgN_LVoQ1dVExkPezFcgKCik5PcsexbgFSJXQPMzOKs6ErGW9ysIHHPRkvYsbu899n0cM85gPeMAhLv-bd1fF928v8ut1wXPtuiUg4meU_O1Xv09DOKuLwe4wj8dxP_kx5tblaTrvrMl3OOnROsx1Oyf1-Dh70Osh4pPb9zz7dHV5c_G2WL9_c33xel0YJsRUyLptqWkAKkBCBNBecMpr7EVLaspawRvadH3aiNUEqWasaRomQbYAreGkPs9enXT3cztiZ9BNQQ9qH-yow1F5bdXfGWc36rM_KCqEkJwngee3AsF_mTFOarTR4DBoh36OijRUSkloQ1MpPZWa4GMM2N_ZEFALLrVVJ1xqwaUIUQlXanv254h3Tb_4_N4h0cCDxZBULDqDnQ1oJtV5-z-HfwXMYBMVPezwiHHr5-ASBEVUrBSoj8vJLBdDWA2Q1qt_ANAYvYA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749991474</pqid></control><display><type>article</type><title>Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Fan, Ni ; Luo, Yayan ; Xu, Ke ; Zhang, Minling ; Ke, Xiaoyin ; Huang, Xini ; Ding, Yi ; Wang, Daping ; Ning, Yuping ; Deng, Xuefeng ; He, Hongbo</creator><creatorcontrib>Fan, Ni ; Luo, Yayan ; Xu, Ke ; Zhang, Minling ; Ke, Xiaoyin ; Huang, Xini ; Ding, Yi ; Wang, Daping ; Ning, Yuping ; Deng, Xuefeng ; He, Hongbo</creatorcontrib><description>AbstractObjectiveExposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed. Methods155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS). ResultsSerum IL-6 and IL-18 levels were significantly higher, while serum TNF-α level was significantly lower among ketamine users than among healthy controls ( p< 0.05). Serum TNF-α levels showed a significant negative association with PANSS total score ( r= − 0.210, p< 0.01) and negative subscore ( r= − 0.300, p< 0.01). No significant association was found between PANSS score and serum levels of IL-6 and IL-18. ConclusionsSerum levels of TNF-α, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2015.11.006</identifier><identifier>PMID: 26589393</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Blood Chemical Analysis ; Cytokines ; Enzyme-Linked Immunosorbent Assay ; Excitatory Amino Acid Antagonists - administration & dosage ; Excitatory Amino Acid Antagonists - adverse effects ; Female ; Humans ; IL-18 ; IL-6 ; Interleukin-18 - blood ; Interleukin-6 - blood ; Ketamine ; Ketamine - administration & dosage ; Ketamine - adverse effects ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Psychiatric/Mental Health ; Schizophrenia ; Schizophrenia - blood ; Schizophrenic Psychology ; Street Drugs - adverse effects ; Substance-Related Disorders - blood ; Substance-Related Disorders - psychology ; TNF-α ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>Schizophrenia research, 2015-12, Vol.169 (1), p.10-15</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-93bb4c70020e11804f86463ef8b1345b86747df150531e4a557775909b00bc613</citedby><cites>FETCH-LOGICAL-c588t-93bb4c70020e11804f86463ef8b1345b86747df150531e4a557775909b00bc613</cites><orcidid>0000-0003-3007-3174</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2015.11.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26589393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Ni</creatorcontrib><creatorcontrib>Luo, Yayan</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Minling</creatorcontrib><creatorcontrib>Ke, Xiaoyin</creatorcontrib><creatorcontrib>Huang, Xini</creatorcontrib><creatorcontrib>Ding, Yi</creatorcontrib><creatorcontrib>Wang, Daping</creatorcontrib><creatorcontrib>Ning, Yuping</creatorcontrib><creatorcontrib>Deng, Xuefeng</creatorcontrib><creatorcontrib>He, Hongbo</creatorcontrib><title>Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>AbstractObjectiveExposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed. Methods155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS). ResultsSerum IL-6 and IL-18 levels were significantly higher, while serum TNF-α level was significantly lower among ketamine users than among healthy controls ( p< 0.05). Serum TNF-α levels showed a significant negative association with PANSS total score ( r= − 0.210, p< 0.01) and negative subscore ( r= − 0.300, p< 0.01). No significant association was found between PANSS score and serum levels of IL-6 and IL-18. ConclusionsSerum levels of TNF-α, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Chemical Analysis</subject><subject>Cytokines</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Excitatory Amino Acid Antagonists - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>IL-18</subject><subject>IL-6</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Ketamine</subject><subject>Ketamine - administration & dosage</subject><subject>Ketamine - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatric/Mental Health</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenic Psychology</subject><subject>Street Drugs - adverse effects</subject><subject>Substance-Related Disorders - blood</subject><subject>Substance-Related Disorders - psychology</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhDRDKkQMJ48R27AsSqlqotAIJytlynAnr3cRe7GSl5a14EZ4Jhy3lz4WTx5qZ75vRb7LsKYGSAOEvt2U0m4CxrICwkpASgN_LVoQ1dVExkPezFcgKCik5PcsexbgFSJXQPMzOKs6ErGW9ysIHHPRkvYsbu899n0cM85gPeMAhLv-bd1fF928v8ut1wXPtuiUg4meU_O1Xv09DOKuLwe4wj8dxP_kx5tblaTrvrMl3OOnROsx1Oyf1-Dh70Osh4pPb9zz7dHV5c_G2WL9_c33xel0YJsRUyLptqWkAKkBCBNBecMpr7EVLaspawRvadH3aiNUEqWasaRomQbYAreGkPs9enXT3cztiZ9BNQQ9qH-yow1F5bdXfGWc36rM_KCqEkJwngee3AsF_mTFOarTR4DBoh36OijRUSkloQ1MpPZWa4GMM2N_ZEFALLrVVJ1xqwaUIUQlXanv254h3Tb_4_N4h0cCDxZBULDqDnQ1oJtV5-z-HfwXMYBMVPezwiHHr5-ASBEVUrBSoj8vJLBdDWA2Q1qt_ANAYvYA</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Fan, Ni</creator><creator>Luo, Yayan</creator><creator>Xu, Ke</creator><creator>Zhang, Minling</creator><creator>Ke, Xiaoyin</creator><creator>Huang, Xini</creator><creator>Ding, Yi</creator><creator>Wang, Daping</creator><creator>Ning, Yuping</creator><creator>Deng, Xuefeng</creator><creator>He, Hongbo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3007-3174</orcidid></search><sort><creationdate>20151201</creationdate><title>Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers</title><author>Fan, Ni ; Luo, Yayan ; Xu, Ke ; Zhang, Minling ; Ke, Xiaoyin ; Huang, Xini ; Ding, Yi ; Wang, Daping ; Ning, Yuping ; Deng, Xuefeng ; He, Hongbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-93bb4c70020e11804f86463ef8b1345b86747df150531e4a557775909b00bc613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Chemical Analysis</topic><topic>Cytokines</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Excitatory Amino Acid Antagonists - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>IL-18</topic><topic>IL-6</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Ketamine</topic><topic>Ketamine - administration & dosage</topic><topic>Ketamine - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatric/Mental Health</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenic Psychology</topic><topic>Street Drugs - adverse effects</topic><topic>Substance-Related Disorders - blood</topic><topic>Substance-Related Disorders - psychology</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Ni</creatorcontrib><creatorcontrib>Luo, Yayan</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Minling</creatorcontrib><creatorcontrib>Ke, Xiaoyin</creatorcontrib><creatorcontrib>Huang, Xini</creatorcontrib><creatorcontrib>Ding, Yi</creatorcontrib><creatorcontrib>Wang, Daping</creatorcontrib><creatorcontrib>Ning, Yuping</creatorcontrib><creatorcontrib>Deng, Xuefeng</creatorcontrib><creatorcontrib>He, Hongbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Ni</au><au>Luo, Yayan</au><au>Xu, Ke</au><au>Zhang, Minling</au><au>Ke, Xiaoyin</au><au>Huang, Xini</au><au>Ding, Yi</au><au>Wang, Daping</au><au>Ning, Yuping</au><au>Deng, Xuefeng</au><au>He, Hongbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>169</volume><issue>1</issue><spage>10</spage><epage>15</epage><pages>10-15</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>AbstractObjectiveExposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed. Methods155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS). ResultsSerum IL-6 and IL-18 levels were significantly higher, while serum TNF-α level was significantly lower among ketamine users than among healthy controls ( p< 0.05). Serum TNF-α levels showed a significant negative association with PANSS total score ( r= − 0.210, p< 0.01) and negative subscore ( r= − 0.300, p< 0.01). No significant association was found between PANSS score and serum levels of IL-6 and IL-18. ConclusionsSerum levels of TNF-α, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26589393</pmid><doi>10.1016/j.schres.2015.11.006</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3007-3174</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Blood Chemical Analysis Cytokines Enzyme-Linked Immunosorbent Assay Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - adverse effects Female Humans IL-18 IL-6 Interleukin-18 - blood Interleukin-6 - blood Ketamine Ketamine - administration & dosage Ketamine - adverse effects Male Middle Aged Psychiatric Status Rating Scales Psychiatric/Mental Health Schizophrenia Schizophrenia - blood Schizophrenic Psychology Street Drugs - adverse effects Substance-Related Disorders - blood Substance-Related Disorders - psychology TNF-α Tumor Necrosis Factor-alpha - blood Young Adult |
| title | Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers |
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