Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

Enhanced levels of platelet/granulocyte aggregates (PGAs) are found in patients suffering from many different inflammatory vascular diseases, and their formation in animal models of vascular disease is associated with increased thromboinflammation and worsened outcomes. The complement system, a part...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-06, Vol.196 (11), p.4671-4680
Hauptverfasser:	Blatt, Adam Z, Saggu, Gurpanna, Kulkarni, Koustubh V, Cortes, Claudio, Thurman, Joshua M, Ricklin, Daniel, Lambris, John D, Valenzuela, Jesus G, Ferreira, Viviana P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Blood Platelets - cytology Blood Platelets - immunology Cell Aggregation Complement C5a - analysis Complement C5a - biosynthesis Complement C5a - immunology Granulocytes - cytology Granulocytes - immunology Humans Properdin - immunology Properdin - isolation & purification
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