HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha (HIF-1α) and 2 alpha (HIF-2α/EPAS1) are in the same family and act as master regulators of the adaptive response to hypoxia. HI...

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Veröffentlicht in:	Scientific reports 2016-06, Vol.6 (1), p.27280, Article 27280
Hauptverfasser:	Feng, Nan, Chen, Haiying, Fu, Sengwang, Bian, Zhaolian, Lin, Xiaolu, Yang, Li, Gao, Yunjie, Fang, Jingyuan, Ge, Zhizheng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 14/19 14/63 38/77 631/80/304 64/116 692/4020/1503/1581 692/699/1503/1581 Adaptor Proteins, Signal Transducing Adult Aged Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Calcium-Binding Proteins Disease Models, Animal Female Gastrointestinal Hemorrhage - drug therapy Gastrointestinal Hemorrhage - genetics Gastrointestinal Hemorrhage - metabolism Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intercellular Signaling Peptides and Proteins - metabolism Male Mice Middle Aged multidisciplinary Receptor, Notch1 - metabolism Science Thalidomide - administration & dosage Thalidomide - pharmacology Up-Regulation - drug effects Vascular Endothelial Growth Factor A - metabolism Vascular Malformations - drug therapy Vascular Malformations - genetics Vascular Malformations - metabolism Vesicular Transport Proteins - metabolism Zebrafish
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