Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics

Mitochondria influence cardiac electrophysiology through energy- and redox-sensitive ion channels in the sarcolemma, with the collapse of energetics believed to be centrally involved in arrhythmogenesis. This study was conducted to determine if preservation of mitochondrial membrane potential (ΔΨm)...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2016-05, Vol.310 (10), p.H1360-H1370
Hauptverfasser:	Alleman, Rick J, Tsang, Alvin M, Ryan, Terence E, Patteson, Daniel J, McClung, Joseph M, Spangenburg, Espen E, Shaikh, Saame Raza, Neufer, P Darrell, Brown, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Arrhythmias, Cardiac - prevention & control Bioenergetics Cardiac arrhythmia Cardiomyocytes Disease Models, Animal Energy Metabolism Exercise Exercise Therapy - methods Glutathione - metabolism Heart Rate Homeostasis Integrative Cardiovascular Physiology and Pathophysiology Isolated Heart Preparation Male Membrane Potential, Mitochondrial Mitochondria, Heart - metabolism Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - metabolism Oxidative Stress Physical Exertion Physiology Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Running Time Factors
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