Heightened TWEAK-NF-κB signaling and inflammation-associated fibrosis in paralyzed muscles of men with chronic spinal cord injury

Individuals with long-standing spinal cord injury (SCI) often present with extreme muscle atrophy and impaired glucose metabolism at both the skeletal muscle and whole body level. Persistent inflammation and increased levels of proinflammatory cytokines in the skeletal muscle are potential contribut...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2016-05, Vol.310 (9), p.E754-E761
Hauptverfasser:	Yarar-Fisher, Ceren, Bickel, C Scott, Kelly, Neil A, Stec, Michael J, Windham, Samuel T, McLain, Amie B, Oster, Robert A, Bamman, Marcas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chronic Disease Cytokine TWEAK Fibrosis Humans Immunoblotting Inflammation Interleukin-6 - genetics Male Middle Aged Muscle Fibers, Skeletal - pathology Muscle Proteins - genetics Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - metabolism Muscular Atrophy - pathology NF-kappa B - metabolism NF-kappa B p50 Subunit - metabolism Organ Size Phosphoproteins - metabolism Receptors, Interleukin-6 - genetics Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Signal Transduction SKP Cullin F-Box Protein Ligases - genetics Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Transcription Factor RelA - metabolism Transcriptome Tripartite Motif Proteins - genetics Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factors - genetics Tumor Necrosis Factors - metabolism TWEAK Receptor Ubiquitin-Protein Ligases - genetics
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