Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients

Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline...

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Veröffentlicht in:	Scientific reports 2016-06, Vol.6 (1), p.27025-27025, Article 27025
Hauptverfasser:	El-Shamy, Ahmed, Pendleton, Matthew, Eng, Francis J., Doyle, Erin H., Bashir, Ali, Branch, Andrea D.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/70 45/77 692/4020/4021/1607/1610/4029 692/4020/4021/234/2513/1551 Amino Acid Substitution Amino acids Asian people Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - virology Drug dosages Female Gene Expression Genotype Genotype & phenotype Hepacivirus - classification Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - virology Humanities and Social Sciences Humans Infections Liver cancer Liver cirrhosis Liver Neoplasms - diagnosis Liver Neoplasms - etiology Liver Neoplasms - virology Male Middle Aged multidisciplinary Mutation Patients Polymorphism, Genetic Population Prospective Studies Proteins Quasispecies Risk RNA, Viral - genetics Science Science (multidisciplinary) Ultrasonic imaging Viral Core Proteins - genetics
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