Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII‐constitutive phosphorylation of RyR2 at site S2814

Key points Mice with Ca2+–calmodulin‐dependent protein kinase (CaMKII) constitutive pseudo‐phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D+/+ mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) Ca2+ leak in diastole and increased propensity to arrhyt...

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Veröffentlicht in:	The Journal of physiology 2016-06, Vol.594 (11), p.3005-3030
Hauptverfasser:	Mazzocchi, G., Sommese, L., Palomeque, J., Felice, J. I., Di Carlo, M. N., Fainstein, D., Gonzalez, P., Contreras, P., Skapura, D., McCauley, M. D., Lascano, E. C., Negroni, J. A., Kranias, E. G., Wehrens, X. H. T., Valverde, C. A., Mattiazzi, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Calcium - metabolism Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cardiovascular Cardiovascular Conditions, Disorders and Treatments Cardiovascular Physiology Gene Knock-In Techniques Hypotheses Kinases Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology Phosphorylation Phosphorylation - physiology Proteins Research Paper Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism
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