sec-Butylpropylacetamide (SPD) has antimigraine properties

Background Though migraine is disabling and affects 12%–15% of the population, there are few drugs that have been developed specifically for migraine prevention. Valproic acid (VPA) is a broad-spectrum antiepileptic drug (AED) that is also used for migraine prophylaxis, but its clinical use is limit...

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Veröffentlicht in:	Cephalalgia 2016-09, Vol.36 (10), p.924-935
Hauptverfasser:	Kaufmann, Dan, Bates, Emily A, Yagen, Boris, Bialer, Meir, Saunders, Gerald H, Wilcox, Karen, White, H Steve, Brennan, KC
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Amides - therapeutic use Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Cell Line, Tumor Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Cortical Spreading Depression - drug effects Cortical Spreading Depression - physiology Male Mice Mice, Inbred C57BL Migraine Disorders - physiopathology Migraine Disorders - prevention & control Valproic Acid - analogs & derivatives Valproic Acid - pharmacology Valproic Acid - therapeutic use
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