Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

The cross-reactivity of T cells with pathogen- and self-derived peptides has been implicated as a pathway involved in the development of autoimmunity. However, the mechanisms that allow the clonal T cell antigen receptor (TCR) to functionally engage multiple peptide-major histocompatibility complexe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2016-06, Vol.126 (6), p.2191-2204
Hauptverfasser:	Cole, David K, Bulek, Anna M, Dolton, Garry, Schauenberg, Andrea J, Szomolay, Barbara, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie, Zhu, Cheng, Miles, John J, Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J, Sewell, Andrew K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens Autoimmune diseases Autoimmunity Biomedical research Cell receptors Clone Cells Cross Reactions Cross reactions (Immunology) Development and progression Experiments Glycerol Health aspects HLA-A Antigens - chemistry HLA-A Antigens - metabolism Humans Insulin - genetics Insulin - immunology Insulin - metabolism Kinetics Ligands Lymphocytes Models, Molecular Observations Oligopeptides - genetics Oligopeptides - immunology Oligopeptides - metabolism Peptides Protein Binding Protein Precursors - genetics Protein Precursors - immunology Protein Precursors - metabolism Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism Sodium T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!